Abscisic Acid Receptors: Past, Present and Future
Abscisic Acid Receptors: Past, Present and Future
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DOI：
10.1111/j.1744-7909.2011.01044.x
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发表时间：
2011-06-01
影响因子：
11.4
通讯作者：
Chen, Jin-Gui
中科院分区：
文献类型：
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作者：
Guo, Jianjun;Yang, Xiaohan;Chen, Jin-Gui
脱落酸（阿坝）是植物体内重要的逆境激素。与早期的研究支持的存在下，膜和细胞质定位的阿坝受体相一致，最近的研究已经确定了多种阿坝受体位于不同的亚细胞位置。这些包括一个叶绿体膜定位受体（叶绿体Mg 2+螯合酶/阿坝受体的H亚基），两个质膜定位受体（G蛋白偶联受体2和GPCR型G蛋白），以及一个胞质/核定位的吡拉菌素抗性（PYR）/PYR样（PYL）/阿坝受体1（RCAR）的调节组分。虽然大多数已鉴定的阿坝受体的下游分子事件目前尚不清楚，但其中之一PYR/PYL/RCAR被发现直接结合并调节长期已知的阿坝信号传导的中心调节因子A组蛋白磷酸酶2C（PP 2C）的活性。与蔗糖非发酵激酶亚家族2（SnRK 2s）蛋白激酶一起，负责阿坝信号感知和转导的中央信号复合物（ABA-PYR-PP 2Cs-SnRK 2s）由丰富的遗传、生理、生化和结构证据支持。多个阿坝受体的鉴定推进了我们对阿坝信号感知和转导的理解，同时增加了额外的复杂性。
Abscisic acid (ABA) is the key plant stress hormone. Consistent with the earlier studies in support of the presence of both membrane-and cytoplasm-localized ABA receptors, recent studies have identified multiple ABA receptors located in various subcellular locations. These include a chloroplast envelope-localized receptor (the H subunit of Chloroplast Mg2+-chelatase/ABA Receptor), two plasma membrane-localized receptors (G-protein Coupled Receptor 2 and GPCR-type G proteins), and one cytosol/nucleus-localized Pyrabactin Resistant (PYR)/PYR-Like (PYL)/Regulatory Component of ABA Receptor 1 (RCAR). Although the downstream molecular events for most of the identified ABA receptors are currently unknown, one of them, PYR/PYL/RCAR was found to directly bind and regulate the activity of a long-known central regulator of ABA signaling, the A-group protein phosphatase 2C (PP2C). Together with the Sucrose Non-fermentation Kinase Subfamily 2 (SnRK2s) protein kinases, a central signaling complex (ABA-PYR-PP2Cs-SnRK2s) that is responsible for ABA signal perception and transduction is supported by abundant genetic, physiological, biochemical and structural evidence. The identification of multiple ABA receptors has advanced our understanding of ABA signal perception and transduction while adding an extra layer of complexity.