Effects of retrograde gene transfer of brain-derived neurotrophic factor in the rostral spinal cord of a compression model in rat
Effects of retrograde gene transfer of brain-derived neurotrophic factor in the rostral spinal cord of a compression model in rat
复制标题
脑源性神经营养因子逆行基因转移对大鼠受压模型脊髓头端的影响
DOI：
10.1007/s11033-012-1651-7
复制
发表时间：
2012
影响因子：
2.8
通讯作者：
Kan Xu
中科院分区：
文献类型：
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作者：
T. Zhao;Yan Li;X. Dai;Junbo Wang;Y. Qi;Jianwei Wang;Kan Xu
脊髓损伤（SCI）后的恢复在人类和实验动物中是罕见的。成年人SCI后，基因表达的变化和这些基因的调节与损伤的病理发展有关。在损伤后时期，损伤区域中高水平的脑源性神经营养因子（BDNF）有助于增强神经保护和轴突再生。基因调控水平的干预有可能促进SCI修复。在这项研究中，腺病毒介导的BDNF注射在病变区（脊髓嘴侧）上调BDNF的表达在损伤区的压缩模型在大鼠，从而保护神经元和增强行为功能。
Recovery after spinal cord injury (SCI) is rare in humans and experimental animals. Following SCI in adults, changes in gene expression and the regulation of these genes are associated with the pathological development of the injury. High levels of brain-derived neurotrophic factor (BDNF) in the injury area during the post-injury period contribute to enhanced neuroprotection and axonal regeneration. Intervention at the level of gene regulation has the potential to promote SCI repair. In this study, the injection of adenovirus-mediated BDNF in the lesion area (rostral spinal cord) up-regulated the expression of BDNF in the injury zone of a compression model in rat, thereby protecting neurons and enhancing behavioral function.
逆行AdV-BDNF/NT-3基因转染脊髓神经元细胞
DOI：
--
发表时间：
2007
期刊：
影响因子：
--
作者：
H. Baba;K. Uchida;H. Nakajima;C. Kubota;T. Yayama
通讯作者：
T. Yayama