The structure, genetic polymorphisms, expression and biological functions of complement receptor type 1 (CR1/CD35)
The structure, genetic polymorphisms, expression and biological functions of complement receptor type 1 (CR1/CD35)
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DOI：
10.3109/08923970902845768
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发表时间：
2009-12-01
影响因子：
3.3
通讯作者：
Niu, Zhong-Xiang
中科院分区：
文献类型：
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作者：
Liu, Dong;Niu, Zhong-Xiang
补体系统由可溶性和细胞表面相关蛋白组成，可识别外源、改变或潜在有害的内源配体。近年来，补体系统，特别是成分 C3 及其受体，已被证明是先天性免疫和适应性免疫之间的关键环节。 1 型补体受体 (CR1) 是 C3b/C4b 补体肽的受体，它已成为深入了解此类疾病的易感性、病理生理学、诊断、预后和治疗的分子。本文对CR1的结构、遗传多态性、表达及生物学功能进行简要介绍。
The complement system is comprised of soluble and cell surface associated proteins that recognize exogenous, altered, or potentially harmful endogenous ligands. In recent years, the complement system-particularly component C3 and its receptors-have been demonstrated to be a key link between innate and adaptive immunity. Complement receptor type 1 (CR1), the receptor for C3b/C4bcomplement peptides, has emerged as a molecule of immense interest in gaining insight to the susceptibility, pathophysiology, diagnosis, prognosis and therapy of such diseases. In this review, we wish to briefly bring forth the structure, genetic polymorphisms, expression and biological functions of CR1.