Factors affecting levodopa effects in Parkinson's disease.
Factors affecting levodopa effects in Parkinson's disease.
复制标题
影响左旋多巴治疗帕金森病效果的因素。
DOI：
10.18926/amo/32303
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发表时间：
2000
影响因子：
0.5
通讯作者：
N. Ogawa
中科院分区：
文献类型：
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作者：
N. Ogawa
左旋多巴因其突出的临床疗效而成为治疗帕金森病（PD）的金标准。然而，大多数患者会出现各种不良反应，包括磨损-脱落现象、开关现象、运动障碍和精神症状。对左旋多巴的反应不仅取决于患者的内在反应性，还取决于各种其他重要因素，包括左旋多巴制剂的类型、其吸收/代谢、血脑屏障、疾病发作时的年龄和抗帕金森病药物的伴随使用。本文就影响左旋多巴治疗帕金森病疗效的因素作一综述。为了最大限度地减少左旋多巴引起的不良反应并缓解长期帕金森病症状，在进行左旋多巴治疗时应考虑这些因素。
Levodopa is the gold standard for the treatment of Parkinson's disease (PD) because of its outstanding clinical efficacy. However, the majority of patients experience various adverse reactions, including the wearing-off phenomenon, the on-off phenomenon, dyskinesia and psychiatric symptoms. The response to levodopa depends not only on the intrinsic responsiveness of the patients, but also on various other important factors including the type of levodopa preparation, its absorption/metabolism, the blood-brain barrier, age at onset of disease and concomitant use of anti-parkinsonian drugs. This review summarizes factors which influence the effects of levodopa in PD. To minimize levodopa-induced adverse reactions and to relieve long-term parkinsonian symptoms, levodopa therapy should be conducted by taking these factors into consideration.