Alterations in beta-adrenergic receptor binding in partially and fully amygdala-kindled juvenile and adult rats.
Alterations in beta-adrenergic receptor binding in partially and fully amygdala-kindled juvenile and adult rats.
复制标题
部分和完全杏仁核点燃的幼年和成年大鼠中β-肾上腺素能受体结合的变化。
DOI：
10.1016/0014-4886(87)90006-9
复制
发表时间：
1987
影响因子：
5.3
通讯作者：
Buterbaugh,GG
中科院分区：
文献类型：
--
作者：
Michelson,HB;Buterbaugh,GG
Twenty-eight-day-old (juvenile) rats were kindled with hourly stimulations to partial or fully kindled status. Adult rats were stimulated with hourly or daily stimulations. Alterations in [3H]dihydroalprenolol binding were determined 3 weeks after the last stimulation. We found that partially kindled, hourly stimulated juvenile rats showed a significant increase in the dissociation constant (Kd), with no change in maximal binding values. Fully kindled juvenile rats showed no change inKdorBmax. Partially kindled, hourly stimulated adult rats showed a significant decrease inKd, with no change inBmax. There was no change inKdorBmaxvalues in fully kindled, hourly stimulated adult rats. Fully kindled, daily stimulated adult rats showed a decrease in maximal binding, with no change inKdvalues. These findings indicate that kindling-induced β-adrenergic receptor alterations were influenced by the age of the animal and the kindling parameters used, as well as the extent to which the animals were kindled.
