Clinical characteristics of multiple sclerosis in Lebanon
Clinical characteristics of multiple sclerosis in Lebanon
复制标题
DOI：
10.1016/j.jns.2008.02.009
复制
发表时间：
2008-07-15
影响因子：
4.4
通讯作者：
El-Hajj, T.
中科院分区：
文献类型：
--
作者：
Yamout, B.;Barada, W.;El-Hajj, T.
多发性硬化症（MS）的流行病学、临床、放射学和实验室特征在高加索人和日本人群中有很好的记录，但对阿拉伯世界的MS知之甚少。随着治疗、MRI技术和其他诊断程序的最新进展，这些知识变得至关重要。我们报告了一组黎巴嫩MS患者，包括他们的临床和实验室特征的细节。我们回顾了202例符合Me Donald诊断标准并在我们的三级护理中心随访的患者的病历。该队列高度代表了黎巴嫩的疾病，其中MS患者的数量估计在1200至1700之间。在我们的队列中，MS的发病高峰年龄在30岁，62.4%的患者在20至39岁之间出现首次症状。女性/男性比例为1.8/1.0。5%的患者存在MS阳性家族史。最常见的临床症状为脑干-小脑（46.2%），其次为感觉（42.5%）、运动（33.9%）和视觉（29.6%）。在患者总数中，85.1%的患者在发病时患有复发缓解型MS，7.9%的患者患有原发性进行性MS。20%的患者存在良性MS，定义为发病10年后EDSS < = 2.0。从发病到继发性进展性MS的平均时间约为9年。视觉、脑干和体感诱发电位异常的患者分别占65.6%、27.8%和50.7%。脑脊液显示32.6%的患者出现白细胞增多，45.2%的患者IgG合成增加，40%的患者出现阳性寡克隆条带，34%的患者出现蛋白质升高。虽然我们的MS人群的一些临床特征与西方系列不同，但疾病的自然史相似。(c)2008 Elsevier B. V.保留所有权利。
The epidemiologic, clinical, radiological and laboratory characterization of multiple sclerosis (MS) is very well documented in Caucasian and Japanese populations, but very little is known about MS in the Arab world. Such knowledge is becoming of paramount importance, with the recent advances in therapies, MRI techniques and other diagnostic procedures. We report a cohort of Lebanese MS patients, including details of their clinical and laboratory characteristics. The medical records of 202 patients fulfilling the Me Donald's diagnostic criteria, and followed in our tertiary care center were reviewed. This cohort is highly representative of the disease in Lebanon where the number of MS patients is estimated to be between 1200 and 1700.The peak age of onset of MS in our cohort was in the third decade with 62.4% of patients developing their first symptoms between 20 and 39 years. The female/male ratio was 1.8/1.0. A positive family history for MS was present in 5% of patients. The most frequent presenting symptoms were brainstem-cerebellar (46.2%) followed by sensory (42.5%), motor (33.9%) and visual (29.6%). Of the total number of patients, 85.1 % had relapsing remitting MS at onset, and 7.9% primary progressive MS. Benign MS defined as EDSS < = 2.0 after 10 years from onset was present in 20% of patients. The mean time from onset to secondary progressive MS was around 9 years. Visual, brainstem, and somatosensory evoked potentials were abnormal in 65.6%, 27.8%, and 50.7% of patients tested respectively. Cerebrospinal fluid showed pleocytosis in 32.6%, increased IgG synthesis in 45.2%, positive oligoclonal bands in 40%, and elevated protein in 34% of patients tested. Although some of the clinical characteristics of our MS population were different compared to western series, the natural history of the disease was similar. (c) 2008 Elsevier B.V. All rights reserved.