The Pax2 homolog sparkling is required for development cone and pigment cells in the Drosophila eye
The Pax2 homolog sparkling is required for development cone and pigment cells in the Drosophila eye
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DOI：
10.1101/gad.11.16.2066
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发表时间：
1997-08-15
影响因子：
10.5
通讯作者：
Noll, M
中科院分区：
文献类型：
--
作者：
Fu, WM;Noll, M
一个新的果蝇Pax基因，闪闪发光（spa），涉及眼睛的发展，被分离和编码同源的脊椎动物Pax2，Pax5和Pax8蛋白。在胚胎神经系统、幼虫和蛹眼盘的视锥细胞、初级色素和刚毛细胞中表达。在SPA（POI）突变体中，增强子的缺失废除了SPA在视锥细胞和初级色素细胞中的表达，并导致非神经元小眼细胞的发育受到严重干扰。视锥细胞中的cat和初级色素细胞中的Bar基因座的激活进一步需要Spa表达。Sire认为在昆虫和脊椎动物眼睛的发育过程中，Spa和帕雷之间有着密切的功能相似性。
A new Drosophila Pax gene, sparkling (spa), implicated in eye development, was isolated and shown to encode the homolog of the vertebrate Pax2, Pax5, and Pax8 proteins. It is expressed in the embryonic nervous system and in cone, primary pigment, and bristle cells of larval and pupal eye discs. In spa(poI) mutants, a deletion of an enhancer abolishes Spa expression in cone and primary pigment cells and results in a severely disturbed development of non-neuronal ommatidial cells. Spa expression is further required for activation of cat in cone cells and of the Bar locus in primary pigment cells. Sire suggest close functional analogies between Spa and Pare in the development of the insect and vertebrate eye.