Economic impacts of alternative kidney transplant immunosuppression: A national cohort study.
Economic impacts of alternative kidney transplant immunosuppression: A national cohort study.
复制标题
DOI：
10.1111/ctr.13813
复制
发表时间：
2020-04
影响因子：
2.1
通讯作者：
中科院分区：
文献类型：
--
作者：
Understanding the economic implications of induction and maintenance immunosuppression (ISx) is important in developing personalized kidney transplant (KTx) care. Using data from a novel integrated data set including financial records from the University Health System Consortium, Medicare, and pharmacy claims (2007-2014), we estimated the differences in the impact of induction and maintenance ISx regimens on transplant hospitalization costs and Medicare payments from KTx to 3 years. Use of thymoglobulin (TMG) significantly increased transplant hospitalization costs ($12 006; P = .02), compared with alemtuzumab and basiliximab. TMG resulted in lower Medicare payments in posttransplant years 1 (−$2058; P = .05) and 2 (−$1784; P = .048). Patients on steroid-sparing ISx incurred relatively lower total Medicare spending (−$10 880; P = .01) compared with patients on triple therapy (tacrolimus, antimetabolite, and steroids). MPA/AZA-sparing, mammalian target of rapamycin inhibitors-based, and cyclosporine-based maintenance ISx regimens were associated with significantly higher payments. Alternative ISx regimens were associated with different KTx hospitalization costs and longer-term payments. Future studies of clinical efficacy should also consider cost impacts to define the economic effectiveness of alternative ISx regimens.
登录
查看更多内容
DOI：
10.1111/ajt.13616
发表时间：
2016-05
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Axelrod D;Segev DL;Xiao H;Schnitzler MA;Brennan DC;Dharnidharka VR;Orandi BJ;Naik AS;Randall H;Tuttle-Newhall JE;Lentine KL
通讯作者：
Lentine KL
影响因子：
120.7
作者：
Engels, Eric A.;Pfeiffer, Ruth M.;Fraumeni, Joseph F., Jr.;Kasiske, Bertram L.;Israni, Ajay K.;Snyder, Jon J.;Wolfe, Robert A.;Goodrich, Nathan P.;Bayakly, A. Rana;Clarke, Christina A.;Copeland, Glenn;Finch, Jack L.;Fleissner, Mary Lou;Goodman, Marc T.;Kahn, Amy;Koch, Lori;Lynch, Charles F.;Madeleine, Margaret M.;Pawlish, Karen;Rao, Chandrika;Williams, Melanie A.;Castenson, David;Curry, Michael;Parsons, Ruth;Fant, Gregory;Lin, Monica
通讯作者：
Lin, Monica
DOI：
10.2215/cjn.03080707
发表时间：
2008-07-01
影响因子：
9.8
作者：
Lentine, Krista L.;Rey, Lisa A. Rocca;Brennan, Daniel C.
通讯作者：
Brennan, Daniel C.
影响因子：
6.2
作者：
Lentine, Krista L.;Gheorghian, Adrian;Schnitzler, Mark A.
通讯作者：
Schnitzler, Mark A.
影响因子：
13.6
作者：
Lentine, KL;Brennan, DC;Schnitzler, MA
通讯作者：
Schnitzler, MA