Worldwide emergence of extensively drug-resistant tuberculosis.
Worldwide emergence of extensively drug-resistant tuberculosis.
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DOI：
10.3201/eid1303.061400
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发表时间：
2007-03
影响因子：
11.8
通讯作者：
Cegielski JP
中科院分区：
文献类型：
--
作者：
Shah NS;Wright A;Bai GH;Barrera L;Boulahbal F;Martín-Casabona N;Drobniewski F;Gilpin C;Havelková M;Lepe R;Lumb R;Metchock B;Portaels F;Rodrigues MF;Rüsch-Gerdes S;Van Deun A;Vincent V;Laserson K;Wells C;Cegielski JP
结核分枝杆菌菌株不仅对最强大的一线药物产生耐药性，而且对许多二线药物也产生耐药性。对越来越多的用于治疗耐多药结核病（MDR-TB）的二线药物具有耐药性的结核分枝杆菌菌株正在成为全球公共卫生的威胁。我们调查了M. 2000-2004年期间对二线抗结核药物耐药的结核病分离株。我们将广泛耐药结核病（XDR-TB）定义为对6类二线药物中的≥3种进一步耐药的耐多药结核病。在23个合格实验室中，14个（61%）提供了17，690株分离株的数据，反映了48个国家的药物敏感性结果。在3，520株（19.9%）耐多药结核分离株中，347株（9.9%）符合广泛耐药结核标准。进一步调查基于人口的趋势，扩大努力预防耐药性和有效治疗耐多药结核病患者，对于保护公共卫生和控制结核病至关重要。
Mycobacterium tuberculosis strains are becoming resistant to not only the most powerful first-line drugs but also many second-line drugs. Mycobacterium tuberculosis strains that are resistant to an increasing number of second-line drugs used to treat multidrug-resistant tuberculosis (MDR-TB) are becoming a threat to public health worldwide. We surveyed the Network of Supranational Reference Laboratories for M. tuberculosis isolates that were resistant to second-line anti-TB drugs during 2000–2004. We defined extensively drug-resistant TB (XDR-TB) as MDR-TB with further resistance to ≥3 of the 6 classes of second-line drugs. Of 23 eligible laboratories, 14 (61%) contributed data on 17,690 isolates, which reflected drug susceptibility results from 48 countries. Of 3,520 (19.9%) MDR-TB isolates, 347 (9.9%) met criteria for XDR-TB. Further investigation of population-based trends and expanded efforts to prevent drug resistance and effectively treat patients with MDR-TB are crucial for protection of public health and control of TB.