Smoking and Risk of Tuberculosis Incidence, Mortality, and Recurrence in South Korean Men and Women
Smoking and Risk of Tuberculosis Incidence, Mortality, and Recurrence in South Korean Men and Women
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DOI：
10.1093/aje/kwp308
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发表时间：
2009-12-15
影响因子：
5
通讯作者：
Samet, Jonathan M.
中科院分区：
文献类型：
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作者：
Jee, Sun Ha;Golub, Jonathan E.;Samet, Jonathan M.
作者探讨了吸烟与结核病发病率、复发率和死亡率的关系。在1，294，504名韩国人中进行了一项为期14年的前瞻性队列研究（1992-2006）。参与者按吸烟史分组，作者评估了每组的结核病发病率、死亡率和复发风险。未校正和校正的考克斯比例风险模型用于研究吸烟史与3个关注结局之间的相关性，校正年龄和饮酒。与从不吸烟者相比，目前吸烟者结核病死亡率在男性（校正风险比（HR）= 1.6，95%置信区间（CI）：1.3，2.0）和女性（HR = 1.6，95% CI：1.0，2.4）中均增加。目前男性吸烟者发生结核病的风险高于既往吸烟者（HR = 1.4，95%CI：1.3，1.5），目前吸烟者的风险随每日吸烟量增加而增加。在女性中，吸烟与结核病发病无关。吸烟和性别对发病率有交互作用（P = 0.00047）。吸烟的影响通常随着体重指数的调整而减少。在男性中，最高饮酒量（>= 100 g/天）与结核病发病风险相关（HR = 1.5，95% CI：1.3，1.7）。这项研究提供了纵向证据，表明吸烟增加了结核病发病率、结核病死亡率和结核病复发的风险。
The authors explored the association of cigarette smoking with tuberculosis incidence, recurrence, and mortality. A 14-year prospective cohort study (1992-2006) was carried out in 1,294,504 South Koreans. Participants were grouped by smoking history, and the authors assessed tuberculosis incidence, mortality, and recurrence risk for each group. Unadjusted and adjusted Cox proportional hazards models were used to investigate the association between smoking history and the 3 outcomes of interest, adjusting for age and alcohol use. Compared with never smokers, current smokers had increased mortality from tuberculosis among both men (adjusted hazard ratio (HR) = 1.6, 95% confidence interval (CI): 1.3, 2.0) and women (HR = 1.6, 95% CI: 1.0, 2.4). Current male smokers had greater risk of incident tuberculosis than former smokers (HR = 1.4, 95% CI: 1.3, 1.5), and risk among current smokers increased with number of cigarettes smoked daily. In females, cigarette smoking was not associated with incident tuberculosis. There was interaction between smoking and sex for incidence (P = 0.00047). The effect of smoking was generally reduced with adjustment for body mass index. Among men, the highest alcohol consumption category (>= 100 g/day) was associated with risk of incident tuberculosis (HR = 1.5, 95% CI: 1.3, 1.7). This study provides longitudinal evidence that smoking increases risk of incident tuberculosis, mortality from tuberculosis, and tuberculosis recurrence.