Phagosomes are competent organelles for antigen cross-presentation
Phagosomes are competent organelles for antigen cross-presentation
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DOI：
10.1038/nature01912
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发表时间：
2003-09-25
期刊：
影响因子：
64.8
通讯作者：
Desjardins, M
中科院分区：
文献类型：
--
作者：
Houde, M;Bertholet, S;Desjardins, M
处理微生物抗原并将其呈递到细胞表面的能力是我们清除感染的先天能力的一个重要方面。一般认为，细胞质中的抗原装载在内质网中，并在主要组织相容性复合体（MHC）I类分子上呈递在细胞表面，而存在于内/吞噬细胞区室中的肽呈递在MHC II类分子上（1，2）。尽管I类和II类途径明显分离，但来自细胞内病原体（包括分枝杆菌、大肠杆菌、鼠伤寒沙门氏菌、流产布鲁氏菌和利什曼原虫）的抗原已显示可引发MHC I类依赖性CD 8（+）T细胞应答（3-7），这一过程称为交叉呈递（2）。允许交叉呈递途径的细胞机制知之甚少。在这里，我们表明，吞噬体显示的元素和属性需要自给自足的外源性抗原的交叉呈递，一个新的归因功能与内质网介导的吞噬作用。
The ability to process microbial antigens and present them at the surface of cells is an important aspect of our innate ability to clear infections. It is generally accepted that antigens in the cytoplasm are loaded in the endoplasmic reticulum and presented at the cell surface on major histocompatibility complex (MHC) class I molecules, whereas peptides present in endo/phagocytic compartments are presented on MHC class II molecules(1,2). Despite the apparent segregation of the class I and class II pathways, antigens from intracellular pathogens including mycobacteria, Escherichia coli, Salmonella typhimurium, Brucella abortus and Leishmania, have been shown to elicit an MHCclass-I-dependent CD8(+) T-cell response(3-7), a process referred to as cross-presentation(2). The cellular mechanisms allowing the cross-presentation pathway are poorly understood. Here we show that phagosomes display the elements and properties needed to be self-sufficient for the cross-presentation of exogenous antigens, a newly ascribed function linked to phagocytosis mediated by the endoplasmic reticulum.