Genetic polymorphisms of exon 1 of MBL2 contribute to tuberculosis risk especially in Asian populations: an updated meta-analysis of 26 studies.
Genetic polymorphisms of exon 1 of MBL2 contribute to tuberculosis risk especially in Asian populations: an updated meta-analysis of 26 studies.
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MBL2 外显子 1 的遗传多态性会增加结核病风险，尤其是在亚洲人群中：26 项研究的最新荟萃分析。
DOI：
10.2147/idr.s168465
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发表时间：
2018
影响因子：
3.9
通讯作者：
Fan ZD
中科院分区：
文献类型：
--
作者：
Wu YJ;Yang X;Chen TD;Zhang ZX;You YZ;Fan ZD
有证据表明，甘露糖结合凝集素2（MBL 2）外显子1的遗传变异可能有助于结核病（TB）的风险。许多研究调查了MBL 2外显子1多态性（rs 1800450、rs 1800451和rs 5030737）与结核病风险之间的关联，但结果不确定。我们对26项符合条件的病例对照研究进行了荟萃分析，其中包括7952例病例和9328例对照，以确定相关性的强度。采用比值比（OR）和95%CI评价关联强度。使用STATA 12.1进行统计分析。我们发现MBL 2外显子1多态性与结核病风险增加之间在三种模型中存在统计学显著相关性：等位基因模型（O vs A：OR =1.18，95%CI：1.01-1.38，P异质性<0.0001，I2=85.8%），纯合子比较（OO vs AA：OR =1.49，95%CI：1.02-2.18，P异质性<0.0001，I2=79.1%），优势模型（AO/OO vs AA：OR =1.20，95%CI：1.01-1.43，P异质性<0.0001，I2=83.5%），尤其是在基于亚洲人群的研究中：等位基因模型（Ovs A：OR =1.29，95%CI：1.11-1.51，P异质性<0.0001，I2=66.0%），纯合子比较（OO vs AA：OR =1.67，95%CI：1.09-2.55，P异质性=0.008，I2=54.2%），杂合子比较（AO vs AA：OR =1.26，95%CI：1.05-1.50，P异质性=0.001，I2=62.9%），优势模型（AO/OO vs. AA：OR =1.31，95%CI：1.10-1.56，P异质性=0.001，I2=64.2%），隐性模型（OO vs AO/AA：OR =1.50，95%CI：1.01-2.22，P异质性=0.023，I2=48.0%）。荟萃回归结果显示，对照来源（p=0.009），而非种族（p=0.687）、基因分型方法（p=0.231）和样本量（p=0.451）导致异质性来源。这项荟萃分析表明，MBL 2外显子1多态性可能有助于结核病的风险，特别是在亚洲人群。
Evidence suggests that genetic variations of exon 1 of mannose-binding lectin 2 (MBL2) may contribute to tuberculosis (TB) risk. Many studies have investigated the association between MBL2 exon 1 polymorphisms (rs1800450, rs1800451, and rs5030737) and TB risk, but yielded inconclusive results. We conducted this meta-analysis of 26 eligible case–control studies that included 7952 cases and 9328 controls to identify the strength of association. Odds ratio (OR) and 95% CI were used to evaluate the strength of association. Statistical analyses were performed by using STATA 12.1. We found a statistically significant correlation between MBL2 exon 1 polymorphisms and increased TB risk among three models: allele model (O vs A: OR =1.18, 95% CI: 1.01–1.38, Pheterogeneity<0.0001, I2=85.8%), homozygote comparison (OO vs AA: OR =1.49, 95%CI: 1.02–2.18, Pheterogeneity<0.0001, I2=79.1%), dominant model (AO/OO vs AA: OR =1.20, 95% CI: 1.01–1.43, Pheterogeneity<0.0001, I2=83.5%), especially in studies based on Asian populations among five models: allele model (O vs A: OR =1.29, 95% CI: 1.11–1.51, Pheterogeneity<0.0001, I2=66.0%), homozygote comparison (OO vs AA: OR =1.67, 95% CI: 1.09–2.55, Pheterogeneity=0.008, I2=54.2%), heterozygote comparison (AO vs AA: OR =1.26, 95% CI: 1.05–1.50, Pheterogeneity=0.001, I2=62.9%), dominant model (AO/OO vs. AA: OR =1.31, 95% CI: 1.10–1.56, Pheterogeneity=0.001, I2=64.2%), and recessive model (OO vs AO/AA: OR =1.50, 95% CI: 1.01–2.22, Pheterogeneity=0.023, I2=48.0%). Meta-regression results revealed that source of controls (p=0.009), but not ethnicity (p=0.687), genotyping method (p=0.231), and sample size (p=0.451) contributed to the source of heterogeneity. This meta-analysis suggests that MBL2 exon 1 polymorphisms may contribute to TB risk, especially in Asian populations.