Chronic mild stress and sucrose consumption: Validity as a model of depression
Chronic mild stress and sucrose consumption: Validity as a model of depression
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DOI：
10.1016/s0031-9384(96)00305-8
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发表时间：
1996-12-01
影响因子：
2.9
通讯作者：
Reid, IC
中科院分区：
文献类型：
--
作者：
Forbes, NF;Stewart, CA;Reid, IC
根据Willner等人（11）的研究，对大鼠进行为期6周的不可预测的轻度应激方案，检查其蔗糖消耗量和偏好。将这些受试者与暴露于以下物质的组进行比较：仅应激方案的食物剥夺元素;或2.没有食物限制的应激协议对照组没有暴露于压力源。与其他2组相比，应激和食物剥夺动物的体重和蔗糖消耗量显著降低。因此，这些变量似乎依赖于食物剥夺和独立的其他元素的压力协议。无论是蔗糖消耗每克体重，也没有蔗糖偏好之间的4组显着差异。这些结果表明，食物剥夺不仅是必要的，但足够的，在大鼠中产生蔗糖消耗赤字。因此，压力大鼠蔗糖消耗量的减少可能仅仅是由于体重减轻，而不是暴露于一系列压力源。我们的结论是，蔗糖消费是不是一个有效的指标奖励反应。当考虑抑郁障碍的压力源模型的有效性时，其他测量（如位置偏好条件反射或颅内自我刺激阈值）也应该根据体重变化进行评估。版权所有（C）1996 Elsevier Science Inc.
Sucrose consumption and preference were examined in rats subjected to a 6-week regimen of unpredictable mild stressors, after Willner et al. (11). These subjects were compared with groups exposed to: 1. only the food deprivation element of the stress protocol; or 2. the stress protocol without the food deprivation element. A control group was not exposed to stressors. Body weight and sucrose consumption were significantly reduced in stressed and food-deprived animals compared to the other 2 groups. These variables therefore appeared dependent on food deprivation and independent of other elements of the stress protocol. Neither sucrose consumption par gram body weight nor sucrose preference differed significantly among the 4 groups. These results indicate that food deprivation is not only necessary, but sufficient, to produce sucrose consumption deficits in rats. It is, therefore, likely that reduced sucrose consumption in stressed rats results solely from diminished body weight rather than exposure to the series of stressors. We conclude that sucrose consumption is not a valid index of reward responsiveness. Other measures (such as place-preference conditioning or intracranial self-stimulation threshold) should be evaluated also with respect to body weight change when considering the validity of stressor-based models of depressive disorder. Copyright (C) 1996 Elsevier Science Inc.