Oritavancin Activity against Staphylococcus aureus Causing Invasive Infections in U. S. and European Hospitals: a 5-Year International Surveillance Program
Oritavancin Activity against Staphylococcus aureus Causing Invasive Infections in U. S. and European Hospitals: a 5-Year International Surveillance Program
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DOI：
10.1128/aac.02482-13
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发表时间：
2014-05-01
影响因子：
4.9
通讯作者：
Jones, Ronald N.
中科院分区：
文献类型：
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作者：
Mendes, Rodrigo E.;Sader, Helio S.;Jones, Ronald N.
在本研究中，奥利万星对金黄色葡萄球菌的模式MIC、MIC 50和MIC 90值分别为0.03、0.03和0.06 μ g/ml。对甲氧西林耐药和敏感分离株以及证明多药耐药（MDR）和非MDR表型的分离株观察到相似的结果（MIC 50/90，0.03/0.06 μ g/ml）。奥利万星（MIC 50/90，0.06/0.12mg/ml）对S.具有升高的达托霉素MIC值的金黄色葡萄球菌（即，1至4 mg/ml）和万古霉素（即，2 mg/ml），其显示MIC结果比更敏感的万古霉素或达托霉素对应物高2倍（MIC 50/90，0.03/0.06 mg/ml），但其在
In this study, oritavancin had modal MIC, MIC50, and MIC90 values of 0.03, 0.03, and 0.06 mu g/ml, respectively, against Staphylococcus aureus. Similar results (MIC50/90, 0.03/0.06 mu g/ml) were observed against methicillin-resistant and -susceptible isolates and those demonstrating multidrug-resistant (MDR) and non-MDR phenotypes. When oritavancin (MIC50/90, 0.06/0.12 mg/ml) was tested against S. aureus with elevated MIC values for daptomycin (i.e., 1 to 4 mg/ml) and vancomycin (i.e., 2 mg/ml), it showed MIC results 2-fold higher than those for the more susceptible vancomycin or daptomycin counterparts (MIC50/90, 0.03/0.06 mg/ml), yet it inhibited these isolates at