Increased Total Tau But Not Amyloid-β42 in Cerebrospinal Fluid Correlates with Short-Term Memory Impairment in Alzheimer's Disease
Increased Total Tau But Not Amyloid-β42 in Cerebrospinal Fluid Correlates with Short-Term Memory Impairment in Alzheimer's Disease
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DOI：
10.3233/jad-2009-1214
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发表时间：
2009-01-01
影响因子：
4
通讯作者：
Lu, Pei-Jung
中科院分区：
文献类型：
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作者：
Lin, Yuh-Te;Cheng, Jiin-Tsuey;Lu, Pei-Jung
鉴于对早期和准确诊断、预测疾病进展和监测AD治疗剂疗效的工具的需求，脑脊液（CSF）生物标志物的研究已成为一个快速增长的研究领域。几项研究报告了关于CSF生物标志物与痴呆严重程度之间关系的相互矛盾的数据。在这项研究中，我们集中在识别CSF生物标志物及其与使用认知能力筛查工具（CASI）测量的不同认知领域的损害的相关性。入选AD患者（n = 28）、非AD痴呆患者（n = 16）、其他神经系统疾病患者（OND，n = 14）和健康对照患者（HC，n = 21）。我们的研究结果显示，与HC和OND组相比，AD患者的CSF总tau（t-tau）水平显着升高，淀粉样蛋白β（42）水平显着降低。此外，我们的数据显示，CSF t-tau水平，而不是A β（42）水平，与AD患者CASI中的短期记忆评分呈负相关（斯皮尔曼：r = -0.444; p = 0.018）。这些数据可能表明，在AD患者中，较高的CSF t-tau水平与更多的NFT病理和更严重的短期记忆损害相关。
Given the need for tools for early and accurate diagnosis, prediction of disease progression, and monitoring efficacy of therapeutic agents for AD, the study of cerebrospinal fluid (CSF) biomarkers has become a rapidly growing field of research. Several studies have reported conflicting data regarding the relationships between CSF biomarkers and dementia severity. In this study, we have focused on the identification of CSF biomarkers and their correlations with the impairment of different cognitive domains measured using the Cognitive Abilities Screening Instrument (CASI). Patients with AD (n = 28), non-AD dementia (n = 16), other neurological disorders (OND, n = 14), and healthy controls (HC, n = 21) were enrolled. Our results revealed significantly higher CSF total tau (t-tau) and lower amyloid-beta(42) levels in AD patients compared with those in HC and OND groups. Moreover, our data show that CSF t-tau levels, but not A beta(42) levels, have an inverse correlation with the score of short-term memory in CASI for patients with AD (Spearman: r = -0.444; p = 0.018). This data might indicate that the higher CSF t-tau level is associated with more NFT pathology and more severe impairment of short-term memory in AD patients.