The in vivo performance of biomagnetic hydroxyapatite nanoparticles in cancer hyperthermia therapy
The in vivo performance of biomagnetic hydroxyapatite nanoparticles in cancer hyperthermia therapy
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DOI：
10.1016/j.biomaterials.2009.04.020
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发表时间：
2009-08-01
期刊：
影响因子：
14
通讯作者：
Lin, Feng-Huei
中科院分区：
文献类型：
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作者：
Hou, Chun-Han;Hou, Sheng-Mou;Lin, Feng-Huei
近年来，热疗治疗癌症引起了越来越多的关注。在这项研究中，我们通过小鼠模型对新型磁性羟基磷灰石纳米颗粒进行了体内癌症热疗研究。首次采用共沉淀法，加入Fe2+制备了磁性羟基磷灰石纳米粒子。然后，将磁性HAP粉(MHAP)和纯HAP粉(HAP)分别与磷酸盐缓冲溶液(PBS)混合。混合物是在肿瘤周围注射的。以实现体温过高。将小鼠置于高频交变磁场感应加热器中。在15天的观察期内，只有注射了MHAP并在磁场中进行治疗的小鼠的肿瘤体积显著缩小。未发现局部复发。小鼠血液试验证明，MHAP粉剂具有良好的生物相容性，皮下注射毒性小。因此，我们新的磁性羟基磷灰石纳米颗粒已经在小鼠模型中显示出治疗效果，毒性很小。在将其应用于人体之前，还需要进行进一步的研究。(C)2009爱思唯尔有限公司。保留所有权利。
Hyperthermia therapy for cancer has drawn more and more attention these days. In this study, we conducted an in vivo cancer hyperthermia study of the new magnetic hydroxyapatite nanoparticles by a mouse model. The magnetic hydroxyapatite nanoparticles were first made by co-precipitation method with the addition of Fe2+. Then, magnetic-HAP powder (mHAP) or pure HAP powder (HAP) was mixed with phosphate buffer solution (PBS), respectively. The mixture was injected around the tumor. In order to achieve hyperthermia. the mice were placed into an inductive heater with high frequency and alternating magnetic field. Only the mice which were injected with mHAP and had been treated inside the magnetic field showed dramatic reduction of tumor volume, in the 15-day observation period. No local recurrence was noted. The blood test of mice proved that mHAP powders possessed good biocompatibility and little toxicity when injected subcutaneously. Therefore, our new magnetic hydroxyapatite nanoparticles have demonstrated therapeutic effect in a mouse model with little toxicity. Further study should be done before its application inside the human body. (C) 2009 Elsevier Ltd. All rights reserved.