Engineered Noble-Metal Nanostructures for in Vitro Diagnostics
Engineered Noble-Metal Nanostructures for in Vitro Diagnostics
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DOI：
10.1021/acs.chemmater.8b04152
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发表时间：
2018-11
影响因子：
8.6
通讯作者：
Zheng Xi;H. Ye;Xiaohu Xia
中科院分区：
文献类型：
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作者：
Zheng Xi;H. Ye;Xiaohu Xia
工程贵金属纳米结构的独特性质使其成为体外诊断（IVD）的多功能和强大的信号传感器。特别是，由于对基础纳米研究的机械理解的增加和高性能分析工具的快速发展，现在可以以原子精度严格调整贵金属纳米结构的物理和化学参数（包括尺寸，形状，元素组成和内部结构）。通过仔细控制这些参数，可以优化金属纳米结构的物理化学性质，从而提高其在IVD中的性能。在这篇文章中，我们介绍了最近开发的方法，有效地工程贵金属纳米结构所需的性能，讨论了工程纳米结构在各种IVD平台的上级性能，并提供深入了解材料的设计，合成和应用在IVD。我们希望这篇文章能成为一个有用的...
The unique properties of engineered noble-metal nanostructures make them versatile and robust signal transducers for in vitro diagnostics (IVDs). Particularly, thanks to the increased mechanistic understanding of fundamental nanoresearch and the rapid advancement of high-performance analytical tools, it is now feasible to tightly tune the physical and chemical parameters (including size, shape, elemental composition, and internal structure) of a noble-metal nanostructure at atomic precision. Through careful control over these parameters, one can optimize the physicochemical properties of a metal nanostructure and thereby enhance its performance in IVDs. In this article, we introduce recently developed methodologies for effectively engineering noble-metal nanostructures with desired properties, discuss the superior performance of the engineered nanostructures in various IVD platforms, and provide insights into materials design, synthesis, and application in IVDs. We hope this article will serve as a useful...