NEURAL-TUBE DEFECTS AND SEX-RATIOS
NEURAL-TUBE DEFECTS AND SEX-RATIOS
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DOI：
10.1002/ajmg.1320260325
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发表时间：
1987-03-01
期刊：
影响因子：
--
通讯作者：
SELLER, MJ
中科院分区：
文献类型：
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作者：
SELLER, MJ
研究了 147 名疑似患有多因素神经管缺陷 (NTD) 胎儿的性别比。总体而言，该比例（男性：女性）为 0.73，预计女性会超出。然而，当NTD根据病变部位进行细分时，性别比例有所不同。全颅裂、无脑畸形伴颈椎裂、全颅畸形和胸椎裂的女性比例高于整体；中颅骨病变的性别比例接近一致，而低位脊柱病变，特别是累及骶骨的病变，则表现出极度偏向男性。这些发现与神经管的形成模式有关。女性似乎容易出现神经系统缺陷，而男性则容易出现管道化缺陷。对这些发现的解释是早期胚胎发育速度可能存在性别差异。
The sex ratio of 147 fetuses with presumed multifactorial neural tube defect (NTD) was studied. Overall, the ratio (males:females) was 0.73 with expected female excess. However, when the NTDs were subdivided according to the site of the lesion, the sex ratios varied. Total craniorachischisis, anencephaly with cervical spina bifida, holoacrania, and thoracic spina bifida showed a greater female excess than that overall; the sex ratio for meroacrania was close to unity, while that for low spinal lesions, particularly those involving the sacrum, showed an extreme bias towards males. These findings are related to the mode of formation of the neural tube. Females seem prone to defects of neurulation and males to defects in canalisation. An explanation for these findings is suggested in possible sex differences in rate of early embryonic development.