Microwave-assisted synthesis of highly crystalline, multifunctional iron oxide nanocomposites for imaging applications
Microwave-assisted synthesis of highly crystalline, multifunctional iron oxide nanocomposites for imaging applications
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DOI：
10.1039/c6ra11819d
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发表时间：
2016-09
期刊：
影响因子：
3.9
通讯作者：
Marc J. Williams;E. Sánchez;Esther Rani Aluri;F. Douglas;D. Maclaren;O. M. Collins;E. Cussen;James D. Budge;Lara C. Sanders;M. Michaelis;C. Smales;J. Cinatl;S. Lorrio;Dirk Krueger;R. T. D. de Rosales;S. Corr
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文献类型：
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作者：
Marc J. Williams;E. Sánchez;Esther Rani Aluri;F. Douglas;D. Maclaren;O. M. Collins;E. Cussen;James D. Budge;Lara C. Sanders;M. Michaelis;C. Smales;J. Cinatl;S. Lorrio;Dirk Krueger;R. T. D. de Rosales;S. Corr
我们报道了一种可重复的一步微波辅助制备多功能磁性纳米复合材料的方法，该方法由超顺磁性氧化铁(Fe3O4)核、聚电解质稳定剂和有机染料组成，不需要后处理。我们对稳定剂聚4-苯磺酸钠(PSSS)和聚磷酸钠(SPP)进行了深入的研究，从电子显微镜、动态光散射测量、磁滞回线和磁共振成像的分析中，我们发现PSSS获得的Fe3O4纳米粒子结晶度较高，与使用SPP作为稳定剂时获得的结晶度较低的纳米粒子相比，可以增强磁性行为，从而获得更好的对比剂松弛性能。我们还展示了利用我们的微波辅助合成获得多功能磁性-荧光纳米复合材料的潜力。通过这种方式，我们展示了合成方法(使用聚电解质稳定剂进行微波加热)和所产生的性质(颗粒大小、形状和磁性)之间的密切联系，以及这如何支持所得到的纳米复合材料作为生物医学成像试剂的功能。
We report a reproducible single-step, microwave-assisted approach for the preparation of multifunctional magnetic nanocomposites comprising superparamagnetic iron oxide (Fe3O4) cores, a polyelectrolyte stabilizer and an organic dye with no requirement for post-processing. The stabilisers poly(sodium 4-styrenesulfonate) (PSSS) and sodium polyphosphate (SPP) have been thoroughly investigated and from analysis using electron microscopy, dynamic light scattering measurements, magnetic hysteresis and magnetic resonance (MR) imaging, we show that the higher degree of Fe3O4 nanoparticle crystallinity achieved with the PSSS stabiliser leads to enhanced magnetic behaviour and thus better contrast agent relaxivity compared to the less crystalline, poorly defined particles obtained when SPP is employed as a stabiliser. We also demonstrate the potential for obtaining a multifunctional magnetic-fluorescent nanocomposite using our microwave-assisted synthesis. In this manner, we demonstrate the intimate link between synthetic methodology (microwave heating with a polyelectrolyte stabilizer) and the resulting properties (particle size, shape, and magnetism) and how this underpins the functionality of the resulting nanocomposites as agents for biomedical imaging.