BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1β administration
BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1β administration
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DOI：
10.1016/j.jneuroim.2004.06.009
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发表时间：
2004-10-01
影响因子：
3.3
通讯作者：
Maier, SF
中科院分区：
文献类型：
--
作者：
Barrientos, RM;Sprunger, DB;Maier, SF
本研究探讨了海马内注射白细胞介素-1 β（IL-1 β）对脑源性神经营养因子（BDNF）mRNA表达的调节作用0.5，2，4和6小时后，上下文恐惧条件反射，一个已知的任务，增加BDNF mRNA，在大鼠。情境恐惧条件反射产生了时间依赖性的增加，不同的海马区的BDNF mRNA。IL-1 β阻断或减少了海马CA 1、CA 2和齿状回区域BDNF mRNA的增加，但对皮质区域没有影响。这些数据支持的想法，IL-1 β产生的记忆缺陷可能是通过介导的海马BDNF mRNA的减少。(C)2004 Elsevier B. V.保留所有权利。
The present study examined the modulating effects of an intrahippocampal injection of interleukin-1beta (IL-1beta) on brain-derived neurotrophic factor (BDNF) mRNA expression 0.5, 2, 4, and 6 h following contextual fear conditioning, a task known to increase BDNF mRNA, in rats. Contextual fear conditioning produced a time-dependent increase in BDNF mRNA that varied by region of hippocampus. IL-1beta blocked or reduced these increases in BDNF mRNA in the CA 1, CA2, and dentate gyrus regions of the hippocampus, but had no effect in cortical regions. These data support the idea that IL-1beta-produced memory deficits may be mediated via BDNF mRNA reductions in hippocampus. (C) 2004 Elsevier B.V. All rights reserved.