Smaller insula and inferior frontal volumes in young adults with pervasive developmental disorders
Smaller insula and inferior frontal volumes in young adults with pervasive developmental disorders
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DOI：
10.1016/j.neuroimage.2010.01.085
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发表时间：
2010-05-01
期刊：
影响因子：
5.7
通讯作者：
Wada, Yuji
中科院分区：
文献类型：
--
作者：
Kosaka, Hirotaka;Omori, Masao;Wada, Yuji
据报道，患有广泛性发育障碍（PDD）的婴儿头围增大和脑重量增加，体积研究表明，患有POD的儿童脑体积异常增大。然而，我们对年轻PDD患者的脑容量异常知之甚少。我们研究了年轻POD患者的灰质（GM）体积。使用3-T磁共振扫描仪获取32名高功能PDD男性（23.8 +/- 4.2岁：全量表智商[FSIQ] = 101.6 +/- 15.6）和40名年龄匹配的正常男性对照（22.5 +/- 4.3岁：FSIQ = 109.7 +/- 7.9）的t1加权体积图像。使用基于体素的形态测量（VBM）和使用指数李代数（DARTEL）的微分形态解剖配准（Diffeomorphic anatomicregistration）来比较两组之间的区域GM体积。与对照组相比，高功能PDD组右侧脑岛、右侧额下回和右侧顶叶下小叶的GM显著减少。保守阈值证实，右侧脑岛和额下回的容量相当小。在这些领域，自闭症谱系商得分与GM体积之间存在负相关，尽管每个受试者的FSIQ与GM体积之间没有显著相关性。在高功能POD组中，没有区域显示出更大的GM体积。岛叶皮层。它作为多个神经认知系统的中继区域，可能是PDD复杂临床特征的关键区域之一。高功能PDD受试者中较小的GM体积可能反映了PDD本身的临床特征，而不是FSIQ。(C) 2010爱思唯尔公司版权所有。
Enlarged head circumference and increased brain weight have been reported in infants with pervasive developmental disorders (PDD), and volumetric studies suggest that children with POD have abnormally enlarged brain volumes. However, little is known about brain volume abnormalities in young adults with PDD. We explored gray matter (GM) volume in young adults with POD. T1-weighted volumetric images were acquired with a 3-T magnetic resonance scanner from 32 males with high-functioning PDD (23.8 +/- 4.2 years: Full Scale Intelligence Quotient [FSIQ] = 101.6 +/- 15.6) and 40 age-matched normal male control subjects (22.5 +/- 4.3 years: FSIQ = 109.7 +/- 7.9). Regional GM volumes were compared between the two groups using voxel-based morphometry (VBM) with the Diffeomorphic Anatomical Registration using Exponentiated Lie algebra (DARTEL). Compared with the control group, the high-functioning PDD group showed significantly less GM in the right insula, the right inferior frontal gyrus, and the right inferior parietal lobule. A conservative threshold confirmed considerably smaller volumes in the right insula and inferior frontal gyrus. In these areas, negative correlations were found between Autism Spectrum Quotient scores and GM volume, although no significant correlations were found between each subject's FSIQ and GM volume. No regions showed greater GM volumes in the high-functioning POD group. The insular cortex. which works as a relay area for multiple neurocognitive systems, may be one of the key regions underlying the complex clinical features of PDD. These smaller GM volumes in high-functioning PDD subjects may reflect the clinical features of PDD itself, rather than FSIQ. (C) 2010 Elsevier Inc. All rights reserved.