Sensing Inhalation Injury-Associated Changes in Airway Wall Compliance by Anatomic Optical Coherence Elastography.
Sensing Inhalation Injury-Associated Changes in Airway Wall Compliance by Anatomic Optical Coherence Elastography.
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DOI：
10.1109/tbme.2020.3037288
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Oldenburg AL
中科院分区：
文献类型：
--
作者：
Bu R;Balakrishnan S;Iftimia N;Price H;Zdanski C;Mitran S;Oldenburg AL
需要定量方法来评估吸入（烧伤）损伤的严重程度，以帮助做出治疗决策。我们假设可以根据气道壁顺应性的差异来评估损伤的严重程度。在这里，我们演示了如何使用定制的内窥镜解剖光学相干弹性成像 (aOCE) 系统来测量气道壁顺应性。该方法首先使用气道模型进行验证，然后在不同程度的吸入（蒸汽）损伤下的离体猪气管上进行。发现 aOCE 衍生的顺应性与蒸汽损伤的严重程度之间存在负相关性，空间分辨的顺应性图揭示了气道特性的区域异质性。
Quantitative methods for assessing the severity of inhalation (burn) injury are needed to aid in treatment decisions. We hypothesize that it is possible to assess the severity of injuries on the basis of differences in the compliance of the airway wall. Here, we demonstrate the use of a custom-built, endoscopic, anatomic optical coherence elastography (aOCE) system to measure airway wall compliance. The method was first validated using airway phantoms, then performed on ex vivo porcine tracheas under varying degrees of inhalation (steam) injury. A negative correlation between aOCE-derived compliance and severity of steam injuries is found, and spatially-resolved compliance maps reveal regional heterogeneity in airway properties.