Differential transmission of Asian and African Zika virus lineages by Aedes aegypti from New Caledonia
Differential transmission of Asian and African Zika virus lineages by Aedes aegypti from New Caledonia
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DOI：
10.1038/s41426-018-0166-2
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发表时间：
2018-09-26
影响因子：
13.2
通讯作者：
Dupont-Rouzeyrol, Myrielle
中科院分区：
文献类型：
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作者：
Calvez, Elodie;O'Connor, Olivia;Dupont-Rouzeyrol, Myrielle
寨卡病毒（ZIKV）是一种由伊蚊传播给人类的黄病毒。寨卡病毒分为两个系统发育谱系，非洲和亚洲。在亚洲谱系中，太平洋和美洲分支与最近全球爆发的寨卡病毒有关。本研究的目的是测量埃及伊蚊对属于这两个谱系的七个寨卡病毒株的媒介能力。我们证明Ae。南太平洋地区新喀里多尼亚（NC）的埃及伊蚊是亚洲寨卡病毒的低能力媒介（传播效率< 10%）。所使用的亚洲寨卡病毒株（2014年和2015年为新喀里多尼亚，太平洋支系，2016年为法属圭亚那，美洲支系）的采样日期和采集地点在媒介能力方面未观察到显著差异。新喀里多尼亚Ae。与最近从非洲（传播效率10%）和亚洲（传播效率< 10%）分离的寨卡病毒相比，属于非洲谱系的早期病毒分离株（感染后9天传播效率约为37%）传播寨卡病毒的能力明显更强。本研究结果表明，Ae。来自NC的埃及伊蚊可被感染并复制属于所有谱系的不同寨卡病毒株。我们的数据强调了根据每个当地地理环境研究媒介和虫媒病毒之间相互作用的重要性。这种方法将提高我们对虫媒病毒传播的认识，以预防它们的出现并改善卫生监测。
Zika virus (ZIKV) is a Flavivirus that is transmitted to humans by Aedes mosquitoes. ZIKV is divided into two phylogenetic lineages, African and Asian. In the Asian lineage, Pacific and American clades have been linked to the recent worldwide outbreak of ZIKV. The aim of this study was to measure the vector competence of Aedes aegypti for seven ZIKV strains belonging to both lineages. We demonstrate that Ae. aegypti from New Caledonia (NC), South Pacific region, is a low-competence vector for Asian ZIKV (< 10% transmission efficiency). No significant differences were observed in vector competence with respect to the sampling date and collection site of Asian ZIKV strains used (2014 and 2015 for New Caledonia, Pacific clade, and 2016 for French Guiana, American clade). The ability of the New Caledonian Ae. aegypti to transmit ZIKV is significantly greater for the earlier viral isolates belonging to the African lineage (> 37% transmission efficiency after 9 days post- infection) compared to recent ZIKV isolates from African (10% transmission efficiency) and Asian lineages (< 10% transmission efficiency). The results of this study demonstrate that Ae. aegypti from NC can become infected and replicate different ZIKV strains belonging to all lineages. Our data emphasize the importance of studying the interaction between vectors and their arboviruses according to each local geographic context. This approach will improve our understanding of arbovirus transmission to prevent their emergence and improve health surveillance.