To sprout or to split? VEGF, Notch and vascular morphogenesis
To sprout or to split? VEGF, Notch and vascular morphogenesis
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DOI：
10.1042/bst20110650
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发表时间：
2011-12-01
影响因子：
3.9
通讯作者：
Banfi, Andrea
中科院分区：
文献类型：
--
作者：
Gianni-Barrera, Roberto;Trani, Marianna;Banfi, Andrea
治疗性血管生成是治疗患有外周或冠状动脉疾病的患者的有吸引力的策略。血管内皮生长因子-A（vascular endothelial growth factor-A，VEGF）是控制发育和出生后血管生长的基本因子。最近发现VEGF和Notch信号通路之间的相互作用调节导致新血管通过发芽生长的形态发生事件。血管生成也可以通过替代过程发生，即肠套叠或血管分裂。然而，关于其在治疗性血管生成中的作用及其分子调控知之甚少。在这篇文章中，我们简要回顾了VEGF剂量如何决定诱导正常或异常血管生成和芽生血管生成的分子调控Notch信号，并比较这一过程与肠套叠。
Therapeutic angiogenesis is an attractive strategy to treat patients suffering from peripheral or coronary artery disease. VEGF (vascular endothelial growth factor-A) is the fundamental factor controlling vascular growth in both development and postnatal life. The interplay between the VEGF and Notch signalling pathway has been recently found to regulate the morphogenic events leading to the growth of new vessels by sprouting. Angiogenesis can also take place by an alternative process, i.e. intussusception or vascular splitting. However, little is known about its role in therapeutic angiogenesis and its molecular regulation. In the present article, we briefly review how VEGF dose determines the induction of normal or aberrant angiogenesis and the molecular regulation of sprouting angiogenesis by Notch signalling, and compare this process with intussusception.