Association of serum microRNAs with islet autoimmunity, disease progression and metabolic impairment in relatives at risk of type 1 diabetes.
Association of serum microRNAs with islet autoimmunity, disease progression and metabolic impairment in relatives at risk of type 1 diabetes.
复制标题
DOI：
10.1007/s00125-017-4294-3
复制
发表时间：
2017-08
期刊：
影响因子：
8.2
通讯作者：
Pugliese A
中科院分区：
文献类型：
--
作者：
Snowhite IV;Allende G;Sosenko J;Pastori RL;Messinger Cayetano S;Pugliese A
MicroRNAs (miRNAs) are key regulators of gene expression and novel biomarkers for many diseases. We investigated the hypothesis that serum levels of some miRNAs would be associated with islet autoimmunity and/or progression to type 1 diabetes. We measured levels of 93 miRNAs most commonly detected in serum. This retrospective cohort study included 150 autoantibody-positive and 150 autoantibody-negative family-matched siblings enrolled in the TrialNet Pathway to Prevention Study. This was a young cohort (mean age = 11 years), and most autoantibody-positive relatives were at high risk because they had multiple autoantibodies, with 39/150 (26%, progressors) developing type 1 diabetes within an average 8.7 months of follow-up. We analysed miRNA levels in relation to autoantibody status, future development of diabetes and OGTT C-peptide and glucose indices of disease progression. Fifteen miRNAs were differentially expressed when comparing autoantibody-positive/negative siblings (range −2.5 to 1.3-fold). but receiver operating characteristic (ROC) analysis indicated low specificity and sensitivity. Seven additional miRNAs were differentially expressed among autoantibody-positive relatives according to disease progression; ROC returned significant AUC values and identified miRNA cut-off levels associated with an increased risk of disease in both cross-sectional and survival analyses. Levels of several miRNAs showed significant correlations (r 0.22-0.55) with OGTT outcomes. miR-21-3p, miR-29a-3p and miR-424-5p had the most robust associations. Serum levels of selected miRNAs are associated with disease progression and confer additional risk of the development of type 1 diabetes in young autoantibody-positive relatives. Further studies, including longitudinal assessments, are warranted to further define miRNA biomarkers for prediction of disease risk and progression.
登录
查看更多内容
DOI：
10.1084/jem.20061692
发表时间：
2006-10-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cobb BS;Hertweck A;Smith J;O'Connor E;Graf D;Cook T;Smale ST;Sakaguchi S;Livesey FJ;Fisher AG;Merkenschlager M
通讯作者：
Merkenschlager M
影响因子：
4.8
作者：
Abuhatzira, Liron;Xu, Huanyu;Notkins, Abner L.
通讯作者：
Notkins, Abner L.
miRNA-375在新诊断的1型糖尿病的儿童的血清中，糖毒性的传感器改变了。
影响因子：
4.3
作者：
Marchand L;Jalabert A;Meugnier E;Van den Hende K;Fabien N;Nicolino M;Madec AM;Thivolet C;Rome S
通讯作者：
Rome S
DOI：
10.1016/j.bbrc.2012.08.082
发表时间：
2012-09-21
影响因子：
3.1
作者：
Bagge, Annika;Clausen, Trine R.;Dalgaard, Louise T.
通讯作者：
Dalgaard, Louise T.
影响因子：
6.2
作者：
Kanak, Mazhar A.;Takita, Morihito;Naziruddin, Bashoo
通讯作者：
Naziruddin, Bashoo