Neoplastic disease after acute coronary syndrome: incidence, duration, and features: the ABC-4 Study on Heart Disease
Neoplastic disease after acute coronary syndrome: incidence, duration, and features: the ABC-4 Study on Heart Disease
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DOI：
10.2459/jcm.0000000000000701
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发表时间：
2018-10-01
影响因子：
3
通讯作者：
Pasquinucci, Mattia
中科院分区：
文献类型：
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作者：
Berton, Giuseppe;Cordiano, Rocco;Pasquinucci, Mattia
AimTo调查的临床特征和恶性肿瘤的发病率在17年的随访中的一个样本的急性冠状动脉综合征（ACS）。MethodsAdria，Bassano，Conegliano，帕多瓦医院-4心脏病研究是一个正在进行的，前瞻性研究的ACS患者的无偏见的人口。基线临床和实验室数据是在住院的前7天在三个不同的重症监护病房。目前的研究包括589例ACS患者的数据。ResultsAt登记，19例患者证实肿瘤。在随访期间，另外99名患者发生恶性肿瘤疾病。发病率为17.8例/1000人-年，约为一般人群的3倍。与既存肿瘤患者相比，患者在入组后发生肿瘤的持续时间较短[风险比=2.0（1.5-2.6），P=0.001]。随访期间死亡的肿瘤患者比存活者发生肿瘤更早[风险比=1.8（1.1-2.9），P=0.01]，持续时间更短[风险比=4.1（2.4-7.0），P
AimTo investigate the clinical features and incidence of malignant neoplasia during 17 years of follow-up in an unselected sample of patients with acute coronary syndrome (ACS).MethodsThe Adria, Bassano, Conegliano, and Padova Hospital-4 Study on Heart Disease is an ongoing, prospective study of an unbiased population of patients with ACS. Baseline clinical and laboratory data were obtained during the first 7 days of hospitalization at three different intensive coronary care units. The current study included data from 589 patients with ACS.ResultsAt enrollment, 19 patients had confirmed neoplasia. During follow-up, 99 additional patients developed malignant neoplastic disease. The incidence rate was 17.8 cases per 1000 person-years, which was about three times higher than that observed in the general population. Patients had a shorter duration of neoplasia when they developed it after enrollment compared with those with preexisting neoplasia [hazard ratio=2.0 (1.5-2.6), P=0.001]. Patients with neoplasia who died during follow-up had an earlier onset of neoplasia [hazard ratio=1.8 (1.1-2.9), P=0.01] and shorter duration than survivors [hazard ratio=4.1 (2.4-7.0), P