Identification of neural projections from the forebrain to the kidney, using the virus pseudorabies
Identification of neural projections from the forebrain to the kidney, using the virus pseudorabies
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DOI：
10.1016/s0165-1838(99)00031-4
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发表时间：
1999-09-24
期刊：
影响因子：
--
通讯作者：
Oldfield, BJ
中科院分区：
文献类型：
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作者：
Sly, DJ;Colvill, L;Oldfield, BJ
这些数据表明，突触连接的神经元链延伸到大鼠肾脏通过几个层次的神经轴从前脑，和终板-一个已知的区域参与体液稳态的调节。将假狂犬病病毒的Bartha株注射到雄性Sprague-Dawley大鼠的肾脏中，导致脊髓节段（T-1-T-8）中的逆行感染，以及大脑的五个自主“运动前”区、延髓的头腹外侧区、延髓的头腹内侧区、中缝核、围栏的A5区和下丘脑的室旁核中的连续感染，以及孤束核、蓝斑核和蓝斑下核。高阶标签被发现在前脑的区域，包括终板，正中视前核，穹窿下器官，内侧视前区，床核的终纹，前腹侧室周核，外侧视前区，视交叉上核，视交叉后核，初级运动皮层，内脏皮质。这种通往肾脏的多突触通路可能形成了前脑结构对肾功能影响的基础。(C)1999 Elsevier Science B. V.保留所有权利。
These data demonstrate a chain of synaptically connected neurons extending to the rat kidney through several levels of the neuraxis from the forebrain, and the lamina terminalis - an area known to be involved in the regulation of body fluid homeostasis. The Bartha strain of pseudorabies virus was injected into the kidney of male Sprague-Dawley rats, resulting in retrograde infections in spinal cord segments (T-1-T-8), and successive infection in five autonomic 'premotor' areas of the brain, the rostroventrolateral medulla, rostroventro-medial medulla, raphe nuclei, A5 region of the pens, and the paraventricular nucleus of the hypothalamus, as well as the nucleus of the solitary tract, locus coeruleus, and subcoeruleus nuclei. Higher order labelling was found in regions of the forebrain, including the organum vasculosum of the lamina terminalis, median preoptic nucleus, subfornical organ, medial preoptic area, bed nucleus of the stria terminalis, anteroventral periventricular nucleus, lateral preoptic area, suprachiasmatic nucleus, retrochiasmatic nucleus, primary motor cortex, and visceral cortex. This polysynaptic pathway to the kidney may form the substrate underlying the impact of forebrain structures on renal function. (C) 1999 Elsevier Science B.V. All rights reserved.