In Vivo Imaging of MSCT and Micro-CT: a Comparison
In Vivo Imaging of MSCT and Micro-CT: a Comparison
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DOI：
10.1055/s-0028-1109817
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发表时间：
2010-04-01
影响因子：
1.8
通讯作者：
Doerfler, A.
中科院分区：
文献类型：
--
作者：
Schwarz, M.;Engelhorn, T.;Doerfler, A.
目的：评估 MSCT 和新型 mu CT 系统与组织学相比评估大鼠恶性脑肿瘤体积的潜力。材料和方法：14 只大鼠接受了 GFP 标记的 F98 神经胶质瘤细胞的立体定向植入。植入后第 10 天，动物接受使用 Iomeprol 的双剂量对比增强 mu CT 和 MSCT 成像。计算 MSCT 和 mu CT 衍生的肿瘤体积，并与作为金标准的组织学（荧光染色）进行比较。结果：mu CT 衍生的肿瘤体积 (69 +/- 23 mm(3)) 和组织学 (81 +/- 14 mm(3)；p > 0.14) 之间具有良好的相关性。然而，与组织学相比，MSCT 显示出明显较小的肿瘤体积 (55 +/- 25 mm(3)) (p < 0.01)，但能够检测到所有动物的肿瘤。结论：μ CT 允许对与组织学高度相关的实验性神经胶质瘤的对比度增强部分进行体内成像。尽管 MSCT 不太适合评估精确的肿瘤体积，但该方法可以可靠地检测大鼠的肿瘤。由于空间分辨率高，μ CT 系统可以在融合成像（例如融合成像）中发挥重要作用。 g。使用多模态 mu CT/PET 或 mu CT/MRI 融合图像评估实验性脑胶质瘤。
Purpose: To evaluate the potential of MSCT and a novel mu CT system to assess the volume of malignant brain tumors in rats compared to histology.Materials and Methods: Fourteen rats underwent stereotactic implantation of GFP-marked F98-glioma cells. On day 10 after implantation, animals received double-dose contrast-enhanced mu CT and MSCT imaging using Iomeprol. MSCT-and mu CT-derived tumor volumes were calculated and compared to histology (fluorescence staining) as the gold standard.Results: There was good correlation between the mu CT-derived tumor volume (69 +/- 23 mm(3)) and histology (81 +/- 14 mm(3); p > 0.14). MSCT, however, showed significantly smaller tumor volumes (55 +/- 25 mm(3)) compared to histology (p < 0.01) but was able to detect the tumors in all animals.Conclusion: mu CT allows in vivo imaging of the contrast-enhancing parts of experimental gliomas with high correlation to histology. Although MSCT is less suitable for assessing exact tumor volume, this method reliably detects tumors in rats. Due to the high spatial resolution, mu CT-systems could play an important role for fusion imaging, e. g. to assess experimental brain gliomas with multimodal mu CT/PET- or mu CT/MRI-fusion images.