The Role of Prenatal, Obstetric and Neonatal Factors in the Development of Autism
The Role of Prenatal, Obstetric and Neonatal Factors in the Development of Autism
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DOI：
10.1007/s10803-010-1114-8
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发表时间：
2011-07-01
影响因子：
3.9
通讯作者：
Bryson, Susan
中科院分区：
文献类型：
--
作者：
Dodds, Linda;Fell, Deshayne B.;Bryson, Susan
我们对1990年至2002年出生于加拿大新斯科舍省的婴儿进行了一项关联数据库队列研究。自闭症的诊断是从2005年的行政数据库与相关的诊断信息中确定的。一个代表遗传易感性的因素被定义为有一个受影响的兄弟姐妹或母亲有精神病或神经病史。在129,733名儿童中，有924名儿童被诊断为自闭症。研究结果表明，在那些遗传易感性低的人中，一些母亲和产科因素可能在自闭症病因学中起独立作用，而在遗传易感儿童中，这些因素似乎起较小的作用。孕前肥胖和怀孕期间体重过度增加对自闭症风险的作用需要进一步调查。
We conducted a linked database cohort study of infants born between 1990 and 2002 in Nova Scotia, Canada. Diagnoses of autism were identified from administrative databases with relevant diagnostic information to 2005. A factor representing genetic susceptibility was defined as having an affected sibling or a mother with a history of a psychiatric or neurologic condition. Among 129,733 children, there were 924 children with an autism diagnosis. The results suggest that among those with low genetic susceptibility, some maternal and obstetric factors may have an independent role in autism etiology whereas among genetically susceptible children, these factors appear to play a lesser role. The role of pre-pregnancy obesity and excessive weight gain during pregnancy on autism risk require further investigation.