DIETARY PHYTOESTROGENS AND CANCER - INVITRO AND INVIVO STUDIES
DIETARY PHYTOESTROGENS AND CANCER - INVITRO AND INVIVO STUDIES
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DOI：
10.1016/0960-0760(92)90359-q
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发表时间：
1992-03-01
影响因子：
4.1
通讯作者：
HASE, T
中科院分区：
文献类型：
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作者：
ADLERCREUTZ, H;MOUSAVI, Y;HASE, T
对30名绝经后妇女(11名杂食者、10名素食者和9名健康的乳腺癌患者)的尿中雌激素、木脂素和异黄酮类(均为二酚)排泄量与血浆性激素结合球蛋白(SHBG)的关系进行了研究。尿总二酚排泄量与血浆SHBG呈显着正相关，剔除体重指数(BMI)确定的体质量混杂效应后，两者仍具有统计学意义。此外，我们还发现血浆SHBG与尿中16-羟雌酮和雌三醇排泄量呈显着负相关，剔除BMI的影响后仍显着。此外，我们观察到肠内酯(Enl)在与雌二醇协同作用和生理浓度下刺激HepG2肝癌细胞合成SHBG。ENL能迅速被肝细胞结合，主要与其单硫酸盐结合。几种木脂素和异黄酮类化合物大豆苷元和马酚被发现与雌二醇竞争结合到大鼠子宫II型雌激素结合部位(S.C.生物类黄酮受体)。提示木脂素和异黄酮类化合物可能通过参与调节血浆SHBG水平而影响性激素的吸收和代谢，从而影响其生物学活性，并可能通过与雌激素竞争II型雌激素结合部位而抑制癌细胞的生长。
Thirty postmenopausal women (11 omnivores, 10 vegetarians and 9 apparently healthy women with surgically removed breast cancer) were investigated with regard to the association of their urinary excretion of estrogens, lignans and isoflavonoids (all diphenols) with plasma sex hormone binding globulin (SHBG). A statistically significant positive correlation between urinary total diphenol excretion and plasma SHBG was found which remained statistically significant after elimination of the confounding effect of body mass determined by body mass index (BMI). Furthermore we found a statistically significant negative correlation between plasma SHBG and urinary excretion of 16-alpha-hydroxyestrone and estriol which also remained significant after eliminating the effect of BMI. Furthermore we observed that enterolactone (Enl) stimulates the synthesis of SHBG by HepG2 liver cancer cells in culture acting synergistically with estradiol and at physiological concentrations. Enl was rapidly conjugated by the liver cells, mainly to its monosulfate. Several lignans and the isoflavonoids daidzein and equol were found to compete with estradiol for binding to the rat uterine type II estrogen binding site (the s.c. bioflavonoid receptor). It is suggested that lignans and isoflavonoids may affect uptake and metabolism of sex hormones by participating in the regulation of plasma SHBG levels and in this way influence their biological activity and that they may inhibit cancer cell growth like some flavonoids by competing with estradiol for the type II estrogen binding sites.