Mesoporous silica-based versatile theranostic nanoplatform constructed by layer-by-layer assembly for excellent photodynamic/chemo therapy
Mesoporous silica-based versatile theranostic nanoplatform constructed by layer-by-layer assembly for excellent photodynamic/chemo therapy
复制标题
通过逐层组装构建的基于介孔二氧化硅的多功能治疗诊断纳米平台，可实现出色的光动力/化疗治疗
DOI：
10.1016/j.biomaterials.2016.11.057
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发表时间：
2017-02-01
期刊：
影响因子：
14
通讯作者：
Zhang, Xian-Zheng
中科院分区：
文献类型：
--
作者：
Chen, Wei-Hai;Luo, Guo-Feng;Zhang, Xian-Zheng
超分子光敏剂（supraPSs）已成为有效的光动力治疗（PDT）试剂。在此，我们提出将超分子光敏剂的组装能力作为一种新策略，用于构建具有多种功能的诊疗一体化纳米平台，旨在实现高性能的肿瘤治疗。通过用逐层（LbL）组装的多层膜包覆负载替拉扎明（TPZ）的介孔二氧化硅纳米粒子（MSNs），获得了多功能纳米平台（TPZ@MCMSN - Gd³⁺），其通过主 - 客体相互作用形成超分子光敏剂，并与顺磁性的Gd³⁺螯合。TPZ@MCMSN - Gd³⁺可被过度表达CD44受体的肿瘤细胞特异性摄取，并对透明质酸酶（HAase）作出反应以触发治疗药物的释放。体内研究证实，TPZ@MCMSN - Gd³⁺在肿瘤部位优先聚集，并在近红外荧光/磁共振成像引导下，通过光动力治疗和生物还原化疗的协同作用显著抑制肿瘤进展。总之，这种基于超分子光敏剂的策略为诊疗一体化纳米平台的构建开辟了新的途径模式。（C）2016爱思唯尔有限公司。保留所有权利。
Supramolecular photosensitizers (supraPSs) have emerged as effective photodynamic therapy (PDT) agents. Here, we propose the assembling capacity of supraPSs as a new strategy to construct theranostic nanoplatform with versatile functions aming at high-performance tumor therapy. By coating tirapazamine (TPZ)-loaded mesoporous silica nanoparticles (MSNs) with layer-by-layer (LbL) assembled multilayer, the versatile nanoplatform (TPZ@MCMSN-Gd3+) was obtained with the formation of supraPSs via host-guest interaction and the chelation with paramagnetic Gd3+. The TPZ@MCMSN-Gd3+ could be specifically uptaken by CD44 receptor overexpressed tumor cells and respond to hyaluronidase (HAase) to trigger the release of therapeutics. As confirmed by in vivo studies, TPZ@MCMSN-Gd3+ showed preferential accumulation in tumor site and significantly inhibited the tumor progression by the collaboration of PDT and bioreductive chemotherapy under NIR fluorescence/MR imaging guidance. Taken together, this supraPSs based strategy paves a new paradigm of the way for the construction of theranostic nanoplatform. (C) 2016 Elsevier Ltd. All rights reserved.