Probiotic encapsulation technology: from microencapsulation to release into the gut.
Probiotic encapsulation technology: from microencapsulation to release into the gut.
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DOI：
10.3390/pharmaceutics4010149
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发表时间：
2012-02-06
期刊：
影响因子：
5.4
通讯作者：
Vandamme T
中科院分区：
文献类型：
--
作者：
Gbassi GK;Vandamme T
益生菌封装技术（PET）具有保护微生物并将其递送到肠道中的潜力。由于有希望的临床前和临床结果，益生菌已被纳入一系列产品。然而，在微胶囊化过程和肠道中普遍存在的条件方面仍有许多挑战需要克服。本文综述了益生菌微胶囊化的方法学途径，包括微胶囊化材料的选择、微胶囊化工艺的选择、微胶囊化益生菌的体外释放研究等，并指出了微胶囊化益生菌研究中存在的问题。
Probiotic encapsulation technology (PET) has the potential to protect microorgansisms and to deliver them into the gut. Because of the promising preclinical and clinical results, probiotics have been incorporated into a range of products. However, there are still many challenges to overcome with respect to the microencapsulation process and the conditions prevailing in the gut. This paper reviews the methodological approach of probiotics encapsulation including biomaterials selection, choice of appropriate technology, in vitro release studies of encapsulated probiotics, and highlights the challenges to be overcome in this area.