Chemoprevention and therapy of cancer by d-limonene.
Chemoprevention and therapy of cancer by d-limonene.
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DOI：
10.1615/critrevoncog.v5.i1.10
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发表时间：
1994
影响因子：
--
通讯作者：
Pamela L. Crowell;Michael N. Gould
中科院分区：
文献类型：
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作者：
Pamela L. Crowell;Michael N. Gould
天然单萜d-柠檬烯对多种啮齿动物实体瘤具有化学预防和化疗活性。柠檬烯在启动过程中的化学预防活性可归因于诱导I相酶和II相酶的诱导，从而导致致癌物解毒。柠檬烯在促进/进展过程中的化学预防活性可能部分是由于抑制了控制生长的小G蛋白，如p21ras的翻译后异戊二烯基化。柠檬烯对乳腺癌的完全消退似乎涉及到组织的再分化。柠檬烯具有多种抗肿瘤作用，具有较高的治疗效率，提示柠檬烯及其相关单萜类化合物在人类恶性肿瘤的化学预防和化疗中可能是有效的。
The naturally occurring monoterpene d-limonene has chemopreventive and chemotherapeutic activity against many rodent solid tumor types. The chemopreventive activity of limonene during initiation can be attributed to the induction of phase I and phase II enzymes, with resulting carcinogen detoxification. The chemopreventive activity of limonene during promotion/progression may be due in part to inhibition of the posttranslational isoprenylation of growth-controlling small G proteins, such as p21ras. The complete regression of mammary carcinomas by limonene appears to involve tissue redifferentiation. The multiple antitumorigenic effects of limonene are attainable at a high therapeutic ratio, suggesting that limonene and related monoterpenes may be efficacious in the chemoprevention and chemotherapy of human malignancies.