Evidence that microplastics aggravate the toxicity of organophosphorus flame retardants in mice (Mus musculus)
Evidence that microplastics aggravate the toxicity of organophosphorus flame retardants in mice (Mus musculus)
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微塑料会加重有机磷阻燃剂对小鼠（Mus musculus）的毒性的证据
DOI：
10.1016/j.jhazmat.2018.06.017
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发表时间：
2018-09-05
影响因子：
13.6
通讯作者：
Lemos, Bernardo
中科院分区：
文献类型：
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作者：
Deng, Yongfeng;Zhang, Yan;Lemos, Bernardo
本研究旨在揭示同时暴露于有机磷阻燃剂（OPFRs）和微塑料（MPs）的健康风险。我们将小鼠暴露于聚乙烯（PE）和聚苯乙烯（PS） MPs和OPFRs[三（2-氯乙基）磷酸（TCEP）和三（1,3-二氯-2-丙基）磷酸（TDCPP）]中90天。采用生化标志物和代谢组学检测MPs是否能增强OPFRs的毒性。10 μ g/L TDCPP + PE组与TDCPP组相比，超氧化物歧化酶（SOD）和过氧化氢酶（CAT）分别提高了21%和26% （p < 0.05）。TDCPP + MPs组乳酸脱氢酶（LDH）高于TDCPP组（18% ~ 30%）（p < 0.05）。TCEP + PE组的乙酰胆碱酯酶（AChE）低于TCEP组（10% ~ 19%）（p < 0.05）。这些结果表明，OPFR与MPs共暴露比单独暴露OPFR诱导的毒性更大。最后，与对照组相比，我们观察到在TCEP、TCEP + PS、TCEP + PE、TDCPP、TDCPP + PS和TDCPP + PE组中，分别有29、41、41、26、40和37种代谢物发生了显著变化（p < 0.05; fold-change > 1.2）。这些代谢产物大多与氨基酸和能量代谢途径有关。我们的研究结果表明，MPs加重了OPFRs的毒性，并突出了MP与其他污染物共暴露的健康风险。
This study was performed to reveal the health risks of co-exposure to organophosphorus flame retardants (OPFRs) and microplastics (MPs). We exposed mice to polyethylene (PE) and polystyrene (PS) MPs and OPFRs [tris (2-chloroethy) phosphate (TCEP) and tris (1,3-dichloro-2-propyl) phosphate (TDCPP)] for 90 days. Biochemical markers and metabolomics were used to determine whether MPs could enhance the toxicity of OPFRs. Superoxide dismutase (SOD) and catalase (CAT) increased (p < 0.05) by 21% and 26% respectively in 10 mu g/L TDCPP + PE group compared to TDCPP group. Lactate dehydrogenase (LDH) in TDCPP + MPs groups were higher (18%-30%) than that in TDCPP groups (p < 0.05). Acetylcholinesterase (AChE) in TCEP + PE groups were lower (10%-19%) than those in TCEP groups (p < 0.05). These results suggested that OPFR co-exposure with MPs induced more toxicity than OPER exposure alone. Finally, in comparison to controls we observed that 29, 41, 41, 26, 40 and 37 metabolites changed significantly (p < 0.05; fold-change > 1.2) in TCEP, TCEP + PS, TCEP + PE, TDCPP, TDCPP + PS and TDCPP + PE groups, respectively. Most of these metabolites are related to pathways of amino acid and energy metabolism. Our results indicate that MPs aggravate the toxicity of OPFRs and highlight the health risks of MP co-exposure with other pollutants.