Regulation of Immune Functions by Non-Neuronal Acetylcholine (ACh) via Muscarinic and Nicotinic ACh Receptors.
Regulation of Immune Functions by Non-Neuronal Acetylcholine (ACh) via Muscarinic and Nicotinic ACh Receptors.
复制标题
非神经元性乙酰胆碱(ACh)通过M受体和烟碱受体对免疫功能的调节。
DOI：
10.3390/ijms22136818
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发表时间：
2021-06-24
影响因子：
5.6
通讯作者：
Fujii T
中科院分区：
文献类型：
--
作者：
Mashimo M;Moriwaki Y;Misawa H;Kawashima K;Fujii T
乙酰胆碱（Acetylcholine，ACh）是胆碱能神经系统中的经典神经递质。然而，现在已知ACh调节各种免疫细胞功能。事实上，T细胞、B细胞和巨噬细胞都表达胆碱能系统的组分，包括ACh、毒蕈碱和烟碱ACh受体（mAChR和nAChR）、胆碱乙酰转移酶、乙酰胆碱酯酶和胆碱转运蛋白。在这篇综述中，我们将讨论ACh在免疫系统中的作用。我们将首先简要描述乙酰胆碱储存在免疫细胞中和从免疫细胞释放的机制。然后，我们将讨论通过mAChR和nAChR激活的T细胞和B细胞上的Ca 2+信号通路，强调ACh对T细胞，B细胞和巨噬细胞功能的重要性，以及其对先天性和获得性（细胞和体液）免疫的影响。最后，我们将讨论两个肽配体，分泌淋巴细胞抗原-6/尿激酶型纤溶酶原激活物受体相关肽-1（SLURP-1）和海马胆碱能神经刺激肽（HCNP），对T细胞胆碱能活性的影响。总的来说，我们强调这样一个事实，即ACh不仅作为一种神经递质发挥作用;它通过mAChRs和nAChRs对免疫细胞产生不同的影响来影响免疫力。
Acetylcholine (ACh) is the classical neurotransmitter in the cholinergic nervous system. However, ACh is now known to regulate various immune cell functions. In fact, T cells, B cells, and macrophages all express components of the cholinergic system, including ACh, muscarinic, and nicotinic ACh receptors (mAChRs and nAChRs), choline acetyltransferase, acetylcholinesterase, and choline transporters. In this review, we will discuss the actions of ACh in the immune system. We will first briefly describe the mechanisms by which ACh is stored in and released from immune cells. We will then address Ca2+ signaling pathways activated via mAChRs and nAChRs on T cells and B cells, highlighting the importance of ACh for the function of T cells, B cells, and macrophages, as well as its impact on innate and acquired (cellular and humoral) immunity. Lastly, we will discuss the effects of two peptide ligands, secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1) and hippocampal cholinergic neurostimulating peptide (HCNP), on cholinergic activity in T cells. Overall, we stress the fact that ACh does not function only as a neurotransmitter; it impacts immunity by exerting diverse effects on immune cells via mAChRs and nAChRs.
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影响因子：
4.8
作者：
de Lucas-Cerrillo, Ana M.;Constanza Maldifassi, M.;Montiel, Carmen
通讯作者：
Montiel, Carmen
影响因子：
4.4
作者：
Bekeredjian-Ding, Isabelle;Inamura, Seiichi;Hartmann, Gunther
通讯作者：
Hartmann, Gunther
影响因子：
16.2
作者：
BONNER, TI;YOUNG, AC;BUCKLEY, NJ
通讯作者：
BUCKLEY, NJ
影响因子：
30.5
作者：
Demetriou P;Abu-Shah E;Valvo S;McCuaig S;Mayya V;Kvalvaag A;Starkey T;Korobchevskaya K;Lee LYW;Friedrich M;Mann E;Kutuzov MA;Morotti M;Wietek N;Rada H;Yusuf S;Afrose J;Siokis A;Oxford IBD Cohort Investigators;Meyer-Hermann M;Ahmed AA;Depoil D;Dustin ML
通讯作者：
Dustin ML
DOI：
10.1111/j.1749-6632.2008.04000.x
发表时间：
2009-01-01
期刊：
MECHANISMS OF EXOCYTOSIS
影响因子：
--
作者：
Dunant, Yves;Cordeiro, J. Miguel;Goncalves, Paula P.
通讯作者：
Goncalves, Paula P.