R1 and R2* Changes in the Human Placenta in Response to Maternal Oxygen Challenge
R1 and R2* Changes in the Human Placenta in Response to Maternal Oxygen Challenge
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DOI：
10.1002/mrm.24581
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发表时间：
2013-11-01
影响因子：
3.3
通讯作者：
Naish, Josephine H.
中科院分区：
文献类型：
--
作者：
Huen, Isaac;Morris, David M.;Naish, Josephine H.
妊娠并发症如先兆子痫和胎儿生长受限有时被认为是由胎盘异常引起的，与缺氧有关。氧增强MRI（R-1对比）和BOLD MRI（R-2* 对比）有可能非侵入性地调查这种氧环境在一个范围内的gestational age.MethodsScanning进行了在1.5 T下，母亲的空气和氧气呼吸在一个单一的胎盘切片在14个健康的孕妇受试者的胎龄21-37周。我们报告了R-1的变化，使用的是一个触发反转恢复涡轮自旋回波序列，这是敏感的PO 2的变化，和R-2* 的变化，使用屏气多梯度回波序列敏感的氧饱和度的变化。结果表明，呼吸空气和氧气时，R-2* 降低（P < 0.0001，配对t检验）。R-1随孕周增加而降低（P < 0.0005，r =-0.835，Pearson相关检验）。孕龄对R-2* changes.ConclusionThe结果表明，无创调查胎盘氧合使用MRI和R-1氧增强MRI孕龄的敏感性的可行性。这些技术有可能为妊娠受损提供独特的非侵入性生物标志物。Magn Reson Med 70：1427-1433，2013. (c)2012 Wiley Periodicals，Inc.
PurposePregnancy complications such as preeclampsia and fetal growth restriction are sometimes thought to be caused by placental abnormalities associated with reduced oxygenation. Oxygen-enhanced MRI (R-1 contrast) and BOLD MRI (R-2* contrast) have the potential to noninvasively investigate this oxygen environment at a range of gestational ages.MethodsScanning was carried out at 1.5 T under maternal air and oxygen breathing in a single placental slice in 14 healthy pregnant subjects of gestational ages 21-37 weeks. We report R-1 changes using a respiratory-triggered inversion recovery-turbo spin-echo sequence, which is sensitive to changes in PO2, and R-2* changes using a breathhold multiple gradient-recalled echo sequence sensitive to changes in oxygen saturation.ResultsSignificant R-1 increases (P < 0.005, paired t-test) and R-2* decreases (P < 0.0001, paired t-test) between air and oxygen breathing were demonstrated. R-1 decreased with gestational age (P < 0.0005, r = -0.835, Pearson correlation test). No significant effect of gestational age on R-2* change was observed.ConclusionThe results demonstrate the feasibility of non-invasive investigation of placental oxygenation using MRI and the sensitivity of R-1 oxygen-enhanced MRI to gestational age. The techniques have the potential to provide unique noninvasive biomarkers in compromised pregnancies. Magn Reson Med 70:1427-1433, 2013. (c) 2012 Wiley Periodicals, Inc.