Fast pouch emptying, delayed small intestinal transit, and exaggerated gut hormone responses after Roux-en-Y gastric bypass
Fast pouch emptying, delayed small intestinal transit, and exaggerated gut hormone responses after Roux-en-Y gastric bypass
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DOI：
10.1111/nmo.12087
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发表时间：
2013-04-01
影响因子：
3.5
通讯作者：
Madsen, J. L.
中科院分区：
文献类型：
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作者：
Dirksen, C.;Damgaard, M.;Madsen, J. L.
背景 Roux-en-Y胃绕道术（RYGB）引起胃肠道解剖结构的广泛变化，导致食欲下降和体重大幅减轻，部分原因是厌食肠道激素的过度释放。方法 为了检查 RYGB 后食物通过胃肠道的改变是否可能导致肠道激素释放的变化，我们使用闪烁扫描技术研究了 17 名 RYGB 后 1 年以上的患者和 9 名健康对照受试者的胃肠动力以及肠道激素胰高血糖素样肽 (GLP)-1 和肽 YY3-36 (PYY3-36) 的分泌。主要结果 进餐结束时，与对照受试者的胃相比，RYGB 患者的育儿袋中保留的液体和固体放射性标记标记物的比例较小（P=0.002 和 P
Background Roux-en-Y gastric bypass (RYGB) causes extensive changes in gastrointestinal anatomy and leads to reduced appetite and large weight loss, which partly is due to an exaggerated release of anorexigenic gut hormones. Methods To examine whether the altered passage of foods through the gastrointestinal tract after RYGB could be responsible for the changes in gut hormone release, we studied gastrointestinal motility with a scintigraphic technique as well as the secretion of the gut hormones glucagon-like peptide (GLP)-1 and peptide YY3-36 (PYY3-36) in 17 patients>1 year after RYGB and in nine healthy control subjects. Key Results At meal completion, a smaller fraction of liquid and solid radiolabeled marker was retained in the pouch of RYGB patients than in the stomach of control subjects (P=0.002 and P