Endothelial Progenitors: A Consensus Statement on Nomenclature.
Endothelial Progenitors: A Consensus Statement on Nomenclature.
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DOI：
10.1002/sctm.16-0360
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发表时间：
2017-05
影响因子：
6
通讯作者：
Stitt AW
中科院分区：
文献类型：
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作者：
Medina RJ;Barber CL;Sabatier F;Dignat-George F;Melero-Martin JM;Khosrotehrani K;Ohneda O;Randi AM;Chan JKY;Yamaguchi T;Van Hinsbergh VWM;Yoder MC;Stitt AW
内皮祖细胞（EPC）的命名仍然不明确，在干细胞领域普遍缺乏一致性，许多不同的细胞亚型一直被归在“EPC”这一术语下。就确认内皮祖细胞表型的标准达成一致将是非常有利的，这应包括详细的免疫表型分析、潜能检测以及与非内皮祖细胞的造血血管生成细胞的明确区分。在这篇综述中，我们试图阻止不加区分地使用“EPC”，而是根据定义细胞表型和功能提出精确的术语。内皮集落形成细胞和髓系血管生成细胞是两种不同且定义明确的细胞类型的例子，它们曾被视为EPC，因为它们都促进血管修复，尽管作用机制完全不同。人们认识到科学命名应该是一个由技术和概念进步驱动的动态过程；因此，现行的“EPC”命名不应该是永久性的，而应该根据有力的科学证据变得更加精确。这一点尤其重要，因为这些细胞因其在健康和疾病中的血管修复作用而被认可，并且在某些情况下，朝着用于细胞治疗的方向发展。《干细胞转化医学》2017年；6：1316 - 1320
Endothelial progenitor cell (EPC) nomenclature remains ambiguous and there is a general lack of concordance in the stem cell field with many distinct cell subtypes continually grouped under the term “EPC.” It would be highly advantageous to agree on standards to confirm an endothelial progenitor phenotype and this should include detailed immunophenotyping, potency assays, and clear separation from hematopoietic angiogenic cells which are not endothelial progenitors. In this review, we seek to discourage the indiscriminate use of “EPCs,” and instead propose precise terminology based on defining cellular phenotype and function. Endothelial colony forming cells and myeloid angiogenic cells are examples of two distinct and well‐defined cell types that have been considered EPCs because they both promote vascular repair, albeit by completely different mechanisms of action. It is acknowledged that scientific nomenclature should be a dynamic process driven by technological and conceptual advances; ergo the ongoing “EPC” nomenclature ought not to be permanent and should become more precise in the light of strong scientific evidence. This is especially important as these cells become recognized for their role in vascular repair in health and disease and, in some cases, progress toward use in cell therapy. Stem Cells Translational Medicine 2017;6:1316–1320