Mapping a sensory-motor network onto a structural and functional ground plan in the hindbrain
Mapping a sensory-motor network onto a structural and functional ground plan in the hindbrain
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DOI：
10.1073/pnas.1012189108
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发表时间：
2011-01-18
影响因子：
11.1
通讯作者：
Fetcho, Joseph
中科院分区：
文献类型：
--
作者：
Koyama, Minoru;Kinkhabwala, Amina;Fetcho, Joseph
斑马鱼幼体的后脑包含一个相对简单的基本平面，其中贯穿整个后脑的神经元排列成条纹，代表在递质标识、形态和转录因子表达方面不同的广泛神经元类别。在这些纹状体内，神经元根据年龄以及结构和功能特性持续堆积，例如轴突范围、输入阻力以及它们在运动中被招募的速度。这里我们讨论的问题是，后脑中许多不同的感觉-运动网络之间的特定网络是如何从这样一个有序的计划中产生的。我们使用转基因系和成对斑块记录相结合的方法来识别后脑网络中的兴奋性和抑制性中间神经元，以寻找由Mauthner细胞发起的逃避行为。我们将这个网络映射到地面平面图上，以表明单个后脑网络是通过以可预测的方式从堆积在条带内的细胞类型的基本广泛图案中提取组件来构建的，这些细胞类型根据它们的年龄以及结构和功能属性。许多不同的专门的后脑网络可能类似地从一个简单的早期模式产生。
The hindbrain of larval zebrafish contains a relatively simple ground plan in which the neurons throughout it are arranged into stripes that represent broad neuronal classes that differ in transmitter identity, morphology, and transcription factor expression. Within the stripes, neurons are stacked continuously according to age as well as structural and functional properties, such as axonal extent, input resistance, and the speed at which they are recruited during movements. Here we address the question of how particular networks among the many different sensory-motor networks in hindbrain arise from such an orderly plan. We use a combination of transgenic lines and pairwise patch recording to identify excitatory and inhibitory interneurons in the hindbrain network for escape behaviors initiated by the Mauthner cell. We map this network onto the ground plan to show that an individual hindbrain network is built by drawing components in predictable ways from the underlying broad patterning of cell types stacked within stripes according to their age and structural and functional properties. Many different specialized hindbrain networks may arise similarly from a simple early patterning.