Adipokines and vascular disease in diabetes.
Adipokines and vascular disease in diabetes.
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DOI：
10.1007/s11892-007-0006-6
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发表时间：
2007-02-01
影响因子：
4.2
通讯作者：
Scalia, Rosario
中科院分区：
文献类型：
--
作者：
Goldstein, Barry J;Scalia, Rosario
脂肪因子，特别是脂联素，由于在调节胰岛素敏感性和血管内皮细胞功能方面的作用，在肥胖相关疾病，包括2型糖尿病的发病机制中被强调。由于心血管疾病占糖尿病患者发病率和死亡率的压倒性比例，研究人员正在积极寻求更好地了解脂肪因子在血管系统中所起的作用，希望这些药物的使用或其信号通路的激活，可能有助于预防微血管和大血管并发症。这篇简短的综述强调了最近关于循环脂肪因子对血管的影响的工作，重点是脂联素，并包括一些关于瘦素和抵抗素的最新发现。这一高度活跃的研究领域已经确定了新的激素机制，通过这些机制，脂肪组织块可以影响血管功能，从而对心血管风险产生重要影响。
Adipokines, in particular adiponectin, have been highlighted in the pathogenesis of obesity-related illnesses, including type 2 diabetes, because of their role in the regulation of insulin sensitivity as well as vascular endothelial function. Since cardiovascular disease accounts for an overwhelming proportion of the morbidity and mortality suffered by patients with diabetes, researchers are actively seeking a better understanding of the role that adipokines play in the vasculature with the hope that the use of these agents, or activation of their signaling pathways, might help prevent micro- and macrovascular complications. This brief review highlights recent work on the vascular effects of circulating adipokines, focusing on adiponectin, and includes some recent findings with leptin and resistin. This highly active area of investigation has identified novel hormonal mechanisms by which the adipose tissue mass can influence vascular function with important consequences for cardiovascular risk.