Autophagy inducers restore impaired autophagy, reduce apoptosis, and attenuate blunted alveolarization in hyperoxia‐exposed newborn rats
Autophagy inducers restore impaired autophagy, reduce apoptosis, and attenuate blunted alveolarization in hyperoxia‐exposed newborn rats
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DOI：
10.1002/ppul.24047
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发表时间：
2018-06
影响因子：
3.1
通讯作者：
Dan Zhang;Lin-lin Wu;Yanna Du;Yuting Zhu;Bingting Pan;Xindong Xue;Jianhua Fu
中科院分区：
文献类型：
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作者：
Dan Zhang;Lin-lin Wu;Yanna Du;Yuting Zhu;Bingting Pan;Xindong Xue;Jianhua Fu
自噬是发育过程中的一个常见过程。异常的自噬可以影响细胞凋亡。以往的研究表明，细胞凋亡是存在于支气管肺发育不良（BPD）。然而，在共存的自噬水平上没有共识。本研究旨在研究自噬的作用和自噬诱导剂在BPD模型中的作用。
Autophagy is a common process during development. Abnormal autophagy can impact cell apoptosis. Previous studies have shown that apoptosis is present during bronchopulmonary dysplasia (BPD). However, there is no consensus on the level of coexisting autophagy. This study was designed to investigate the role of autophagy and the effects of autophagy inducers in a BPD model.