Association of exposure to phenols and idiopathic male infertility
Association of exposure to phenols and idiopathic male infertility
复制标题
接触酚类物质与特发性男性不育症的关联
DOI：
10.1016/j.jhazmat.2013.01.061
复制
发表时间：
2013-04-15
影响因子：
13.6
通讯作者：
Wang, Xinru
中科院分区：
文献类型：
--
作者：
Chen, Minjian;Tang, Rong;Wang, Xinru
最近有记录表明，人类广泛接触苯酚，一些潜在的内分泌干扰物苯酚已在动物和体外研究中证明对男性生殖产生不利影响。然而，接触苯酚和男性不育对人类的影响却很少。对 877 名特发性不育男性和 713 名生育对照进行了病例对照研究。测量尿液中双酚 A、二苯甲酮-3、五氯苯酚、三氯生、4-叔辛基苯酚 (4-t-OP)、4-正辛基苯酚 (4-n-OP) 和 4-正壬基苯酚 (4-n-NP) 的含量以及精液参数。经过多变量调整后，我们发现 4-t-OP、4-n-OP 和 4-n-NP 暴露与特发性男性不育症相关（趋势 p 值：
Widespread human exposure to phenols has been documented recently, and some phenols which are potential endocrine disruptors have demonstrated adverse effects on male reproduction in animal and in vitro studies. However, implications about exposure to phenols and male infertility are scarce in humans. Case-control study of 877 idiopathic infertile men and 713 fertile controls was conducted. Urinary levels of bisphenol A, benzophenone-3, pentachlorophenol, triclosan, 4-tert-octylphenol (4-t-OP), 4-n-octylphenol (4-n-OP) and 4-n-nonylphenol (4-n-NP) and semen parameters were measured. After multivariate adjustment, we found 4-t-OP, 4-n-OP and 4-n-NP exposure was associated with idiopathic male infertility (p-value for trend: