Clinical presentation of young people (11-24 years old) with brain tumors: results from the international MOBI-Kids study
Clinical presentation of young people (11-24 years old) with brain tumors: results from the international MOBI-Kids study
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患有脑肿瘤的年轻人（11-24 岁）的临床表现：国际 MOBI-Kids 研究的结果
DOI：
10.1007/s11060-020-03437-4
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发表时间：
2020
影响因子：
3.9
通讯作者：
etal
中科院分区：
文献类型：
--
作者：
Angela ;Zume-;Marne;Michael Kundi;Gemma Casta-Vinyals;etal
我们使用来自MOBI-Kids的数据，这是一项14个国家的脑肿瘤（BTs）国际合作病例对照研究，旨在研究年龄较大儿童肿瘤的临床特征（10岁或以上），青少年和年轻人方法收集899例BT患者的临床资料，包括症状和体征、症状发作、诊断日期、肿瘤类型和位置。结果总体而言，64%的所有肿瘤是低级别的，76%是神经上皮肿瘤和62%的胶质瘤。神经上皮和胚胎性肿瘤中男性多于女性，而脑膜肿瘤中女性多于男性。最常见的部位是小脑（22%）和额叶（16%）。最常见的症状是头痛（60%），以及神经胶质瘤、胚胎性和“非神经上皮”肿瘤;神经上皮肿瘤（非神经胶质瘤）是惊厥/癫痫发作，脑膜瘤是视觉体征和症状。聚类分析显示，头痛和恶心/呕吐是唯一超过50%临界值的症状组合，联合发生率为67%。总体而言，从第一个症状到诊断的中位时间为1.42个月（IQR 0.53-4.80），它超过1年的12%的情况下，虽然没有特定的症状与异常长或短delays.ConclusionsThis是迄今为止进行的最大的临床流行病学研究的BT在年轻人。发现了许多体征和症状，主要是头痛和恶心/呕吐。诊断通常是快速的，但在12%的诊断延迟超过1年，没有一个症状与一个明显的长时间，直到诊断。
IntroductionWe used data from MOBI-Kids, a 14-country international collaborative case–control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24).MethodsInformation from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location.ResultsOverall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were more males than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The most frequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall, as well as for gliomas, embryonal and ‘non-neuroepithelial’ tumors; it was convulsions/seizures for neuroepithelial tumors other than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that headaches and nausea/vomiting was the only combination of symptoms that exceeded a cutoff of 50%, with a joint occurrence of 67%. Overall, the median time from first symptom to diagnosis was 1.42 months (IQR 0.53–4.80); it exceeded 1 year in 12% of cases, though no particular symptom was associated with exceptionally long or short delays.ConclusionsThis is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identified, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnostic delay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis.