Agelamadins A and B, Dimeric Bromopyrrole Alkaloids from a Marine Sponge Agelas sp.
Agelamadins A and B, Dimeric Bromopyrrole Alkaloids from a Marine Sponge Agelas sp.
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DOI：
10.1021/ol501664b
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发表时间：
2014-08-01
期刊：
影响因子：
5.2
通讯作者：
Kobayashi, Jun'ichi
中科院分区：
文献类型：
--
作者：
Kusama, Taishi;Tanaka, Naonobu;Kobayashi, Jun'ichi
从海绵Agelas sp.中分离得到两种结构独特的二聚溴吡咯生物碱Agelamadins A（1）和B（2）。Agelamadins A（1）和B（2）具有共同的由agelastatin样四环部分和oroidin样线性部分组成的结构。化合物1和2的结构经波谱分析鉴定。对琼脂糖菌素A（1）和B（2）的抗菌活性和细胞毒性进行了评价。
Two structurally unique dimeric bromopyrrole alkaloids, agelamadins A (1) and B (2), were isolated from a marine sponge Agelas sp. Agelamadins A (1) and B (2) have a structure consisting of an agelastatin-like tetracyclic moiety and an oroidin-like linear moiety in common. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. The antimicrobial activity and cytotoxicity of agelamadins A (1) and B (2) were evaluated.