FLAN: a web server for influenza virus genome annotation.
FLAN: a web server for influenza virus genome annotation.
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DOI：
10.1093/nar/gkm354
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发表时间：
2007-07
影响因子：
14.9
通讯作者：
Tatusova, Tatiana
中科院分区：
文献类型：
--
作者：
Bao, Yiming;Bolotov, Pavel;Dernovoy, Dmitry;Kiryutin, Boris;Tatusova, Tatiana
FLAN（FLu ANnotation的缩写），用于流感病毒基因组注释的NCBI网络服务器（http：//www.ncbi.nlm.nih.gov/genomes/FLU/Database/annotation.cgi）是用于用户提供的甲型流感病毒或B流感病毒序列的工具。它可以验证和预测由输入流感序列编码的蛋白质序列。将输入序列与包含流感序列的数据库进行BLAST，以确定甲型流感病毒的血凝素和神经氨酸酶片段的病毒类型（A或B）、片段（1至8）和亚型。对于病毒的每个片段/亚型，保持一组样品蛋白质序列。然后用“蛋白质-核苷酸比对工具”（ProSplign）将输入序列与相应的蛋白质组进行比对。将来自与样品蛋白质序列的最佳比对的翻译产物用作由输入序列编码的预测蛋白质。输出可以是可用于序列提交至GenBank（通过Sequin或tbl 2asn）的特征表、GenBank平面文件或FASTA格式的预测蛋白质序列。还将显示一条消息，显示输入序列的长度、甲型流感病毒血凝素和神经氨酸酶片段的预测病毒类型、片段和亚型。
FLAN (short for FLu ANnotation), the NCBI web server for genome annotation of influenza virus (http://www.ncbi.nlm.nih.gov/genomes/FLU/Database/annotation.cgi) is a tool for user-provided influenza A virus or influenza B virus sequences. It can validate and predict protein sequences encoded by an input flu sequence. The input sequence is BLASTed against a database containing influenza sequences to determine the virus type (A or B), segment (1 through 8) and subtype for the hemagglutinin and neuraminidase segments of influenza A virus. For each segment/subtype of the viruses, a set of sample protein sequences is maintained. The input sequence is then aligned against the corresponding protein set with a ‘Protein to nucleotide alignment tool’ (ProSplign). The translated product from the best alignment to the sample protein sequence is used as the predicted protein encoded by the input sequence. The output can be a feature table that can be used for sequence submission to GenBank (by Sequin or tbl2asn), a GenBank flat file, or the predicted protein sequences in FASTA format. A message showing the length of the input sequence, the predicted virus type, segment and subtype for the hemagglutinin and neuraminidase segments of Influenza A virus will also be displayed.