Health-related quality of life and cancer clinical trials.
Health-related quality of life and cancer clinical trials.
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DOI：
10.1177/1758834010395342
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发表时间：
2011-03-01
影响因子：
4.9
通讯作者：
Osoba, David
中科院分区：
文献类型：
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作者：
Osoba, David
衡量患者报告的结果，包括与健康有关的生活质量，是过去四十年来出现和发展起来的一项新举措。在开发可靠和有效的自我报告问卷之后，对数万名患者和各种癌症的健康相关生活质量进行了评估。这篇综述是基于过去十年发表的精选数据，主要针对医疗保健专业人员。临床试验中的评估对于阐明各种癌症及其治疗对患者生命的影响特别有用，并提供了额外的信息，增强了用于确定治疗益处和毒性的常用临床终点。随着经验的增长，与健康有关的研究质量得到了提高，总的来说，最近的研究在方法上可能比前几十年进行的研究更可靠。健康相关的生活质量已经成为比其他一些临床参数（如工作状态）更准确的生存预测指标。临床试验中患者报告结果的常规评估的总体前景是确定的，并且最终可能成为临床实践的标准部分。然而，仍然需要一种明确的方法来确定分数变化的临床意义。答案可能来自更多地使用患者报告的结果，以及由此产生的做出此类判断所必需的经验增长。
The measurement of patient-reported outcomes, including health-related quality of life, is a new initiative which has emerged and grown over the past four decades. Following the development of reliable and valid self-report questionnaires, health-related quality of life has been assessed in tens of thousands of patients and a wide variety of cancers. This review is based on a selection of data published in the last decade and is intended primarily for healthcare professionals. The assessments in clinical trials have been particularly useful for elucidating the effects of various cancers and their treatments on patients' lives and have provided additional information that enhances the usual clinical endpoints used for determining the benefits and toxicity of treatment. With growing experience the quality of the health-related quality of studies has improved and, in general, recent studies are more likely to be methodologically robust than those that were performed in earlier decades. Health-related quality of life has become a more accurate predictor of survival than some other clinical parameters, such as performance status. The overall outlook for the routine assessment of patient-reported outcomes in clinical trials is assured and, eventually, it is likely to become a standard part of clinical practice. However, there is still a need for a clear method for determining the clinical meaningfulness of changes in scores. The answer will probably come from the greater use of patient-reported outcomes and the consequent growth of experience that is necessary to make such judgements.