A Supramolecular Antibiotic Switch for Antibacterial Regulation
A Supramolecular Antibiotic Switch for Antibacterial Regulation
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用于抗菌调节的超分子抗生素开关
DOI：
10.1002/anie.201504566
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发表时间：
2015-11-02
影响因子：
16.6
通讯作者：
Wang, Shu
中科院分区：
文献类型：
--
作者：
Bai, Haotian;Yuan, Huanxiang;Wang, Shu
描述了一种超分子抗生素开关，其可以根据需要可逆地打开和关闭其抗菌活性，为调节生物的抗菌活性的方法提供了概念验证。该开关依赖于阳离子聚对苯撑乙烯衍生物（PPV）与葫芦[7]脲（CB[7]）的超分子组装和拆卸来调节它们与细菌的不同相互作用。这种简单而有效的策略不需要对抗菌剂的活性位点进行任何化学修饰，并且还可以调节光动力疗法中经典抗生素或光敏剂的抗菌活性。从长远来看，这种超分子抗生素开关可能是对抗细菌感染和减少细菌对抗生素耐药性的成功策略。
A supramolecular antibiotic switch is described that can reversibly turn-on and turn-off its antibacterial activity on demand, providing a proof-of-concept for a way to regulate antibacterial activity of biotics. The switch relies on supramolecular assembly and disassembly of cationic poly(phenylene vinylene) derivative (PPV) with cucurbit[7]uril (CB[7]) to regulate their different interactions with bacteria. This simple but efficient strategy does not require any chemical modification on the active sites of the antibacterial agent, and could also regulate the antibacterial activity of classical antibiotics or photosensitizers in photodynamic therapy. This supramolecular antibiotic switch may be a successful strategy to fight bacterial infections and decrease the emergence of bacterial resistance to antibiotics from a long-term point of view.