Mitophagy in degenerative joint diseases.
Mitophagy in degenerative joint diseases.
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退行性关节疾病中的线粒体自噬。
DOI：
10.1080/15548627.2020.1822097
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发表时间：
2021-09
期刊：
影响因子：
13.3
通讯作者：
Guo F
中科院分区：
文献类型：
--
作者：
Sun K;Jing X;Guo J;Yao X;Guo F
线粒体功能障碍与衰老和多种退行性疾病有关，包括椎间盘退行性变(IVDD)和骨关节炎(OA)。因此，维持线粒体的动态平衡和功能非常重要。有丝分裂是一种通过自噬机制选择性地清除受损或功能失调的线粒体的过程，其功能是维持线粒体的质量控制和动态平衡。IVDD和OA是相似的关节疾病，涉及软骨组织的降解，主要由氧化应激、细胞凋亡和细胞外基质(ECM)降解引起。在过去的十年里，越来越多的证据表明，有丝分裂在IVDD和OA的发病机制中扮演着重要的角色。重要的是，通过调控有丝分裂的策略在临床前实验中发挥了有益的作用。鉴于有丝分裂的重要性和新颖性，我们对有丝分裂的途径进行了概述，并讨论了有丝分裂在IVDD和OA中的作用。我们还强调了靶向吞丝分裂治疗退行性关节疾病的潜力。缩写：AD：阿尔茨海默病；AF：纤维环；ADORA2A/A2AR：腺苷A2a受体；AMBRA1：自噬和Beclin 1调节因子1；BMSCs：骨髓间充质干细胞；BNIP3：BCL2相互作用蛋白3；BNIP3L/NIX：BCL2/腺病毒E1B相互作用蛋白3样；CDH6：钙粘蛋白6；CEP：软骨终板；CircRNA：环状RNA；DNM1L/Drp1：动力蛋白1；ECM：细胞外基质；HIF1a：缺氧诱导因子1：α亚单位；IL1B：1β；IMM：线粒体膜；IVDD：间盘退变；MAPK8/JNK：丝裂原激活蛋白8；Mfn1：丝裂原激活蛋白1；MFN2：Mitofusin 2；MIA：碘乙酸单钠；RHOT/MIRO：RAS同源家族成员T；MMPs：线粒体跨膜电位；CALCOCO2/NDP52：钙结合和卷曲结构域2；NFE2L2：核因子：红系2样蛋白2；NP：髓核；OA：骨关节炎；OPA1：OPA1：线粒体动力蛋白样GTPase；OPTN：视神经磷酸酶；PRKN：Parkin RBR E3泛素蛋白连接酶；PD：帕金森病；PGAM5：PGAM5：家族成员5；PPARC1A/PGC-1A：过氧体增殖物受体：γ：辅活化子1α；PHF23：PhD指蛋白23；PINK1：PTEN；ROS：氧物种；PKN：激活的泛素蛋白连接酶；PD：帕金森病；PGAM5：家族成员5；PPARC1A/PGC-1A：过氧体增殖物受体：γ：辅活化子1α；PHF23：PhD指蛋白23；PINK1：诱导的酪氨酸酶；ROS：氧物种；激活的泛素蛋白连接酶；PD：帕金森病；PGAM5：家族成员5；PPARC1A/PGC-1A：过氧体增殖体受体：γ：辅活化子1α；PHF23：PhD指蛋白23；PINK1：PTEN；ROS：氧物种；SfMSCs：滑液MSCs；SIRT1：sirtuin 1；SIRT2：sirtuin 2；SIRT3：sirtuin 3；SQSTM1/p62：隔离体1；肿瘤坏死因子；Ub：泛素；Ubl：泛素样蛋白；VDAC：电压依赖性阴离子通道。
Mitochondrial dysfunction is involved in aging and multiple degenerative diseases, including intervertebral disc degeneration (IVDD) and osteoarthritis (OA). Thus, the maintenance of mitochondria homeostasis and function is important. Mitophagy, a process that selectively clears damaged or dysfunctional mitochondria through autophagic machinery, functions to maintain mitochondrial quality control and homeostasis. IVDD and OA are similar joint diseases involving the degradation of cartilaginous tissues that are mainly caused by oxidative stress, cell apoptosis and extracellular matrix (ECM) degradation. Over the past decade, accumulating evidence indicates the essential role of mitophagy in the pathogenesis of IVDD and OA. Importantly, strategies by the regulation of mitophagy exert beneficial effects in the pre-clinical experiments. Given the importance and novelty of mitophagy, we provide an overview of mitophagy pathways and discuss the roles of mitophagy in IVDD and OA. We also highlight the potential of targeting mitophagy for the treatment of degenerative joint diseases. Abbreviations: AD: Alzheimer disease; AF: annulus fibrosus; ADORA2A/A2AR: adenosine A2a receptor; AMBRA1: autophagy and beclin 1 regulator 1; BMSCs: bone marrow mesenchymal stem cells; BNIP3: BCL2 interacting protein 3; BNIP3L/NIX: BCL2/adenovirus E1B interacting protein 3-like; CDH6: cadherin 6; CEP: cartilaginous endplates; circRNA: circular RNA; DNM1L/DRP1: dynamin 1-like; ECM: extracellular matrix; HIF1A: hypoxia inducible factor 1: alpha subunit; IL1B: interleukin 1 beta; IMM: inner mitochondrial membranes; IVDD: intervertebral disc degeneration; MAPK8/JNK: mitogen-activated protein kinase 8; MFN1: mitofusin 1; MFN2: mitofusin 2; MIA: monosodium iodoacetate; RHOT/MIRO: ras homolog family member T; MMP: mitochondrial transmembrane potential; CALCOCO2/NDP52: calcium binding and coiled-coil domain 2; NFE2L2: nuclear factor: erythroid 2 like 2; NP: nucleus pulposus; OA: osteoarthritis; OPA1: OPA1: mitochondrial dynamin like GTPase; OPTN: optineurin; PRKN: parkin RBR E3 ubiquitin protein ligase; PD: Parkinson disease; PGAM5: PGAM family member 5; PPARGC1A/PGC-1A: peroxisome proliferator activated receptor: gamma: coactivator 1 alpha; PHF23: PHD finger protein 23; PINK1: PTEN induced putative kinase 1; ROS: reactive oxygen species; SfMSCs: synovial fluid MSCs; SIRT1: sirtuin 1; SIRT2: sirtuin 2; SIRT3: sirtuin 3; SQSTM1/p62: sequestosome 1; TNF: tumor necrosis factor; Ub: ubiquitin; UBL: ubiquitin-like; VDAC: voltage-dependent anion channel.
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影响因子：
7
作者：
Ansari MY;Khan NM;Ahmad I;Haqqi TM
通讯作者：
Haqqi TM
线粒体自噬是骨髓间充质干细胞针对氧化损伤的保护性反应
影响因子：
6.1
作者：
Fan, Pan;Yu, Xiao-Yu;Wang, Yun-Tao
通讯作者：
Wang, Yun-Tao
影响因子：
3.5
作者：
Cornelissen, Tom;Haddad, Dominik;Vandenberghe, Wim
通讯作者：
Vandenberghe, Wim
DOI：
10.1073/pnas.1613040114
发表时间：
2017-01-10
影响因子：
11.1
作者：
Aguirre, Jacob D.;Dunkerley, Karen M.;Shaw, Gary S.
通讯作者：
Shaw, Gary S.
影响因子：
4.8
作者：
Castro, Cristina M.;Corciulo, Carmen;Cronstein, Bruce N.
通讯作者：
Cronstein, Bruce N.