On multiple alternating steady states induced by periodic spin phase perturbation waveforms.
On multiple alternating steady states induced by periodic spin phase perturbation waveforms.
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关于由周期性自旋相位扰动波形引起的多个交替稳态。
DOI：
10.1002/mrm.23105
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发表时间：
2012
影响因子：
3.3
通讯作者：
Liu,ThomasT
中科院分区：
文献类型：
--
作者：
Buračas,GiedriusT;Jung,Youngkyoo;Lee,Jongho;Buxton,RichardB;Wong,EricC;Liu,ThomasT
通过MRI直接测量神经电流可能会打开一个高时间分辨率(10-100ms)的窗口，适用于监测神经元活动的动力学，而不会损失MRI提供的高空间分辨率。以前，我们已经证明，交变平衡稳态成像对弱周期电流具有很高的灵敏度，这是因为它放大了周期性的自旋相位扰动。然而，这项技术需要将这种微扰与射频脉冲精确同步。在此，我们将交变平衡稳态成像推广到多个平衡交变稳态成像，以估计神经电流波形。仿真和模型实验表明，多个交变稳态信号的非共振轮廓携带了驱动波形的频率成分的信息。此外，相对于射频脉冲，该方法对精确的波形定时的敏感度低于交替平衡稳态。因此，多稳态交替成像技术有可能应用于周期性神经元活动波形的磁共振成像。Magn Reson Med，2012。©2011 Wiley期刊，Inc.
Direct measurement of neural currents by means of MRI can potentially open a high temporal resolution (10–100 ms) window applicable for monitoring dynamics of neuronal activity without loss of the high spatial resolution afforded by MRI. Previously, we have shown that the alternating balanced steady state imaging affords high sensitivity to weak periodic currents owing to its amplification of periodic spin phase perturbations. This technique, however, requires precise synchronization of such perturbations to the radiofrequency pulses. Herein, we extend alternating balanced steady state imaging to multiple balanced alternating steady states for estimation of neural current waveforms. Simulations and phantom experiments show that the off‐resonance profile of the multiple alternating steady state signal carries information about the frequency content of driving waveforms. In addition, the method is less sensitive than alternating balanced steady state to precise waveform timing relative to radiofrequency pulses. Thus, multiple alternating steady state technique is potentially applicable to MR imaging of the waveforms of periodic neuronal activity. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.