CONDUCTION BLOCK AND DENERVATION IN GUILLAIN-BARRE POLYNEUROPATHY
CONDUCTION BLOCK AND DENERVATION IN GUILLAIN-BARRE POLYNEUROPATHY
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DOI：
10.1093/brain/107.1.219
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发表时间：
1984-01-01
期刊：
影响因子：
14.5
通讯作者：
FEASBY, TE
中科院分区：
文献类型：
--
作者：
BROWN, WF;FEASBY, TE
在急性格林-巴-罗综合征（GBS）的头两周内，两种主要的电生理异常是传导阻滞，在一些患者中，最大M反应幅度低。在本研究期间，最大运动和感觉传导速度通常在正常范围内，时间弥散相对较少。传导阻滞在一些周围神经的分布是普遍化的，而在另一些周围神经的传导阻滞主要是在近端或远端。传导异常超过近端或远端是常见的卡压部位。疾病早期非常低的M反应幅度与随后的肌肉去神经支配的发展和频率以及不利的临床恢复密切相关。我们认为传导阻滞是GBS急性麻痹和感觉丧失的主要原因。轴突变性在急性疾病中起着不同的作用，但它是持久残疾的主要原因。
The two main electrophysiological abnormalities seen in the first two weeks of the acute Guillain-Barré syndrome (GBS) were conduction block and, in some patients, low maximum M response amplitudes. In this study period, maximum motor and sensory conduction velocities were often in the normal range and temporal dispersion was relatively less common. The conduction block was generalized in its distribution in some peripheral nerves, while in others the block was predominantly proximal or distal in location. Conduction abnormalities in excess of those proximal or distal to it were frequent at common sites of entrapment. Very low M response amplitudes early in the course of the disease correlated well with the subsequent development and frequency of denervation in the muscle(s) and unfavourable clinical recovery. We conclude that conduction block is the main cause of the acute paralysis and sensory loss in the GBS. Axonal degeneration contributes variably to the acute disorder, but is the main cause of lasting disability.